Adipogénesis y osteoporosis

Mesenchymal stem cells (MSCs) found in bone marrow stroma, are able to differentiate into osteoblasts and adipocytes, among other cellphenotypes. In normal bone marrow balance osteoblastic an adipocytes cell differentiation favour bone formation, while in osteoporosis there is an increased adipocyte...

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Autores principales:	Rodríguez,Juan Pablo, Astudillo,Pablo, Ríos,Susana, Seitz,Germán, Pino,Ana María
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Adipogenesis Mesenchymal stem cells Osteoporosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000600015
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spelling	oai:scielo:S0034-988720090006000152009-09-04Adipogénesis y osteoporosisRodríguez,Juan PabloAstudillo,PabloRíos,SusanaSeitz,GermánPino,Ana María Adipogenesis Mesenchymal stem cells Osteoporosis Mesenchymal stem cells (MSCs) found in bone marrow stroma, are able to differentiate into osteoblasts and adipocytes, among other cellphenotypes. In normal bone marrow balance osteoblastic an adipocytes cell differentiation favour bone formation, while in osteoporosis there is an increased adipocytes content. Since osteoblasts and adipocytes originate from a common MSC precursor cell, here we discuss whether quantitative and qualitative stem cell defects may be the cause of alterations in the number and function of differentiated cells. This review analyzes some conditions that contribute to different osteogenic/adipogenic potentials in human bone marrow MSCs obtained from control and osteoporotic postmenopausal women. We analyze the protective effect exerted by locally generated factors like estradiol and leptin on MSCs differentiation, because altered bioavailability of these factors may play a role in osteoporosis. Osteoporotic MSCs (o-MSCs) are characterized by increased adipogenic potential as compared to control cells. Leptin exerted a direct protective action against adiposeness only in control cells. In contrast, leptin action on o-MSCs is hampered, suggesting that inadequate leptin action may be associated to lipid accumulation in bone marrow.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.6 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000600015es10.4067/S0034-98872009000600015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adipogenesis Mesenchymal stem cells Osteoporosis
spellingShingle	Adipogenesis Mesenchymal stem cells Osteoporosis Rodríguez,Juan Pablo Astudillo,Pablo Ríos,Susana Seitz,Germán Pino,Ana María Adipogénesis y osteoporosis
description	Mesenchymal stem cells (MSCs) found in bone marrow stroma, are able to differentiate into osteoblasts and adipocytes, among other cellphenotypes. In normal bone marrow balance osteoblastic an adipocytes cell differentiation favour bone formation, while in osteoporosis there is an increased adipocytes content. Since osteoblasts and adipocytes originate from a common MSC precursor cell, here we discuss whether quantitative and qualitative stem cell defects may be the cause of alterations in the number and function of differentiated cells. This review analyzes some conditions that contribute to different osteogenic/adipogenic potentials in human bone marrow MSCs obtained from control and osteoporotic postmenopausal women. We analyze the protective effect exerted by locally generated factors like estradiol and leptin on MSCs differentiation, because altered bioavailability of these factors may play a role in osteoporosis. Osteoporotic MSCs (o-MSCs) are characterized by increased adipogenic potential as compared to control cells. Leptin exerted a direct protective action against adiposeness only in control cells. In contrast, leptin action on o-MSCs is hampered, suggesting that inadequate leptin action may be associated to lipid accumulation in bone marrow.
author	Rodríguez,Juan Pablo Astudillo,Pablo Ríos,Susana Seitz,Germán Pino,Ana María
author_facet	Rodríguez,Juan Pablo Astudillo,Pablo Ríos,Susana Seitz,Germán Pino,Ana María
author_sort	Rodríguez,Juan Pablo
title	Adipogénesis y osteoporosis
title_short	Adipogénesis y osteoporosis
title_full	Adipogénesis y osteoporosis
title_fullStr	Adipogénesis y osteoporosis
title_full_unstemmed	Adipogénesis y osteoporosis
title_sort	adipogénesis y osteoporosis
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000600015
work_keys_str_mv	AT rodriguezjuanpablo adipogenesisyosteoporosis AT astudillopablo adipogenesisyosteoporosis AT riossusana adipogenesisyosteoporosis AT seitzgerman adipogenesisyosteoporosis AT pinoanamaria adipogenesisyosteoporosis
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Adipogénesis y osteoporosis

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