Desde la displasia hasta el cáncer de la vesícula biliar

Background: There is scarcity of knowledge about the development of gallbladder cancer. Aim: To study the features of development and progression of gallbladder cancer. Material and methods: Review of histopathological studies of gallbladder obtained in 25,971 cholecytectomies performed in patients...

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Autores principales:	Roa E,Iván, Muñoz N,Sergio, Ibacache S,Gilda, de Aretxabala U,Xabier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Cholecystectomy Gallbladder neoplasms Metaplasia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700002
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spelling	oai:scielo:S0034-988720090007000022010-04-29Desde la displasia hasta el cáncer de la vesícula biliarRoa E,IvánMuñoz N,SergioIbacache S,Gildade Aretxabala U,Xabier Cholecystectomy Gallbladder neoplasms Metaplasia Background: There is scarcity of knowledge about the development of gallbladder cancer. Aim: To study the features of development and progression of gallbladder cancer. Material and methods: Review of histopathological studies of gallbladder obtained in 25,971 cholecytectomies performed in patients aged 45± 16 years, 79% females, between 1993 and 2004. Among these, 210 had a dysplasia not associated to cancer and 1,039 had a gallbladder cancer Clinical and morphological parameters of preneoplastic and neoplastic lesions were analyzed. Ninety five percent of patients were followed. Results: All cases of dysplasia were incidental findings. Metaplasia, dysplasia and carcinoma in situ were present in the adjacent mucosa in 66%, 81% y 69% of gallbladder carcinomas, respectively. Twenty five percent of gallbladders studied were carcinomas (mucous carcinoma in 18% and muscular carcinoma in 7%). Ninety two percent of cases had chronic inflammation in the gallbladder wall. Seventy two percent of mucous carcinomas were not detected macroscopically Five years survival of mucous carcinoma was 92%. There was an association between the intensity of the lesion and the age of the patients. The age difference between chronic cholecystitis and gallbladder cancer was 11 years for women and nine for men. Conclusions: From a morphological standpoint, the period in which a dysplasia becomes a carcinoma is approximately 10years.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.7 20092009-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700002es10.4067/S0034-98872009000700002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cholecystectomy Gallbladder neoplasms Metaplasia
spellingShingle	Cholecystectomy Gallbladder neoplasms Metaplasia Roa E,Iván Muñoz N,Sergio Ibacache S,Gilda de Aretxabala U,Xabier Desde la displasia hasta el cáncer de la vesícula biliar
description	Background: There is scarcity of knowledge about the development of gallbladder cancer. Aim: To study the features of development and progression of gallbladder cancer. Material and methods: Review of histopathological studies of gallbladder obtained in 25,971 cholecytectomies performed in patients aged 45± 16 years, 79% females, between 1993 and 2004. Among these, 210 had a dysplasia not associated to cancer and 1,039 had a gallbladder cancer Clinical and morphological parameters of preneoplastic and neoplastic lesions were analyzed. Ninety five percent of patients were followed. Results: All cases of dysplasia were incidental findings. Metaplasia, dysplasia and carcinoma in situ were present in the adjacent mucosa in 66%, 81% y 69% of gallbladder carcinomas, respectively. Twenty five percent of gallbladders studied were carcinomas (mucous carcinoma in 18% and muscular carcinoma in 7%). Ninety two percent of cases had chronic inflammation in the gallbladder wall. Seventy two percent of mucous carcinomas were not detected macroscopically Five years survival of mucous carcinoma was 92%. There was an association between the intensity of the lesion and the age of the patients. The age difference between chronic cholecystitis and gallbladder cancer was 11 years for women and nine for men. Conclusions: From a morphological standpoint, the period in which a dysplasia becomes a carcinoma is approximately 10years.
author	Roa E,Iván Muñoz N,Sergio Ibacache S,Gilda de Aretxabala U,Xabier
author_facet	Roa E,Iván Muñoz N,Sergio Ibacache S,Gilda de Aretxabala U,Xabier
author_sort	Roa E,Iván
title	Desde la displasia hasta el cáncer de la vesícula biliar
title_short	Desde la displasia hasta el cáncer de la vesícula biliar
title_full	Desde la displasia hasta el cáncer de la vesícula biliar
title_fullStr	Desde la displasia hasta el cáncer de la vesícula biliar
title_full_unstemmed	Desde la displasia hasta el cáncer de la vesícula biliar
title_sort	desde la displasia hasta el cáncer de la vesícula biliar
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700002
work_keys_str_mv	AT roaeivan desdeladisplasiahastaelcancerdelavesiculabiliar AT munoznsergio desdeladisplasiahastaelcancerdelavesiculabiliar AT ibacachesgilda desdeladisplasiahastaelcancerdelavesiculabiliar AT dearetxabalauxabier desdeladisplasiahastaelcancerdelavesiculabiliar
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Desde la displasia hasta el cáncer de la vesícula biliar

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