Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos

Background: There is paucity of knowledge on the proliferative features of normal or chronically inflamed gallbladder and the mechanisms of development of gallbladder cancer. Aim: To study the proliferation features of non tumoral gallbladder mucosa through the expression of Ki-67 antigen in tissue...

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Autores principales:	Roa E,Iván, Elorza D,Xabier, Lantadilla H,Soledad, Ibacache S,Gilda, de Aretxabala U,Xabier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Gallbladder neoplasms Ki-67 antigen Microarray analysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700003
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spelling	oai:scielo:S0034-988720090007000032010-04-29Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidosRoa E,IvánElorza D,XabierLantadilla H,SoledadIbacache S,Gildade Aretxabala U,Xabier Gallbladder neoplasms Ki-67 antigen Microarray analysis Background: There is paucity of knowledge on the proliferative features of normal or chronically inflamed gallbladder and the mechanisms of development of gallbladder cancer. Aim: To study the proliferation features of non tumoral gallbladder mucosa through the expression of Ki-67 antigen in tissue micro array analysis. Material and methods: The immunohystochemical expression of Ki-67 in tissue micro array was studied in 96 samples of non tumoral gallbladder mucosa (coming from 74 females aged 45±16 years and 22 males aged 53±16 years) and 102 samples of gallbladder cancer (coming from 84 females aged 62± 14 years and 18 males aged 70± 13 years). Results: The staining index of Ki-67 expression was 19±25% (range 096-8996) in samples of non tumoral mucosa and 46±29% (range 396-9896) in gallbladder cancer (p <0.01). Ki-67 was expressed in less than 10% of epithelial cells in 55% of non tumoral mucosa samples and 6% of gallbladder cancer samples. Seventy five percent of gallbladder cancer samples had a staining index of more than 20%. An expression of Ki-67 over 20% or 50% was observed in 25% and 15% of non tumoral mucosa samples, respectively Conclusions: Non tumoral gallbladder mucosa samples have a high proliferation index, measured using Ki-67 immunohystochemical expression. There is a group of samples with cellular hyper-proliferation that maybe related to the pathogenesis of gallbladder cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.7 20092009-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700003es10.4067/S0034-98872009000700003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gallbladder neoplasms Ki-67 antigen Microarray analysis
spellingShingle	Gallbladder neoplasms Ki-67 antigen Microarray analysis Roa E,Iván Elorza D,Xabier Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
description	Background: There is paucity of knowledge on the proliferative features of normal or chronically inflamed gallbladder and the mechanisms of development of gallbladder cancer. Aim: To study the proliferation features of non tumoral gallbladder mucosa through the expression of Ki-67 antigen in tissue micro array analysis. Material and methods: The immunohystochemical expression of Ki-67 in tissue micro array was studied in 96 samples of non tumoral gallbladder mucosa (coming from 74 females aged 45±16 years and 22 males aged 53±16 years) and 102 samples of gallbladder cancer (coming from 84 females aged 62± 14 years and 18 males aged 70± 13 years). Results: The staining index of Ki-67 expression was 19±25% (range 096-8996) in samples of non tumoral mucosa and 46±29% (range 396-9896) in gallbladder cancer (p <0.01). Ki-67 was expressed in less than 10% of epithelial cells in 55% of non tumoral mucosa samples and 6% of gallbladder cancer samples. Seventy five percent of gallbladder cancer samples had a staining index of more than 20%. An expression of Ki-67 over 20% or 50% was observed in 25% and 15% of non tumoral mucosa samples, respectively Conclusions: Non tumoral gallbladder mucosa samples have a high proliferation index, measured using Ki-67 immunohystochemical expression. There is a group of samples with cellular hyper-proliferation that maybe related to the pathogenesis of gallbladder cancer.
author	Roa E,Iván Elorza D,Xabier Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier
author_facet	Roa E,Iván Elorza D,Xabier Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier
author_sort	Roa E,Iván
title	Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
title_short	Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
title_full	Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
title_fullStr	Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
title_full_unstemmed	Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos
title_sort	proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. expresión de ki-67 en matrices de tejidos
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700003
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Proliferación celular en la mucosa de la vesícula biliar no tumoral en colecistitis crónicas litiásicas. Expresión de Ki-67 en matrices de tejidos

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