Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile
Background: Children under oncological therapy are at risk of infection by hepatitis B virus (HBV). Aim: To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material and methods: Collaborative, mult...
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Sociedad Médica de Santiago
2009
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oai:scielo:S0034-988720090007000072010-04-29Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de ChileZubieta,MarcelaSantolaya,María EHurtado,CarmenAlvarez,Ana MAvilés,Carmen LBecker,AnaBrahm,JavierSalgado,CarmenSilva,PamelaTopelberg,SantiagoTordecilla,JuanVaras,MónicaVillarroel,MilenaViviani,Tamara Antineoplastic protocols Blood component transfusion Hepatitis B virus Background: Children under oncological therapy are at risk of infection by hepatitis B virus (HBV). Aim: To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material and methods: Collaborative, multi-centric study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia, from 6 hospitals belonging to the public health network in the Metropolitan Region, between June 2004 and August 2006. These samples were stored at -70-'C. In September 2006, 200 samples were randomly chosen and 170 analyzed to determine hepatitis B virus surface antigen (HBsAg) and anticore total antibodies (anti HBc) by fluorescent ELISA (Enzyme Linked Immunosorbent Assay). In five cases in which a low volume of sample was available, only one marker was studied (HBsAg in two and anti HBc in three). Results: Samples carne from children aged 4 months to 18 years, 104 males (61%). They had received an average of 38 transfusions (range 3-107) from 65 donors (range 3-345). Twelve children were found positive for some marker of HBV: HBsAg in three (1.8%) and anti HBc in ten (7%). In 5 patients that had negative HBsAg and positive anti HBc, anti surface antigen antibodies (anti HBs) were determined and resulted positive in four Conclusions: The prevalence of HBV in this sample was 7% if both serologic markers are considered and 1.8% if only HBsAg is considered.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.7 20092009-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700007es10.4067/S0034-98872009000700007 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Antineoplastic protocols Blood component transfusion Hepatitis B virus |
| spellingShingle |
Antineoplastic protocols Blood component transfusion Hepatitis B virus Zubieta,Marcela Santolaya,María E Hurtado,Carmen Alvarez,Ana M Avilés,Carmen L Becker,Ana Brahm,Javier Salgado,Carmen Silva,Pamela Topelberg,Santiago Tordecilla,Juan Varas,Mónica Villarroel,Milena Viviani,Tamara Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| description |
Background: Children under oncological therapy are at risk of infection by hepatitis B virus (HBV). Aim: To determine the prevalence of infection of HBV in children with cancer who have undergone chemotherapy or have had a hematopoietic stem cell transplant. Material and methods: Collaborative, multi-centric study. Serum samples were collected from 281 children with cancer and episodes of febrile neutropenia, from 6 hospitals belonging to the public health network in the Metropolitan Region, between June 2004 and August 2006. These samples were stored at -70-'C. In September 2006, 200 samples were randomly chosen and 170 analyzed to determine hepatitis B virus surface antigen (HBsAg) and anticore total antibodies (anti HBc) by fluorescent ELISA (Enzyme Linked Immunosorbent Assay). In five cases in which a low volume of sample was available, only one marker was studied (HBsAg in two and anti HBc in three). Results: Samples carne from children aged 4 months to 18 years, 104 males (61%). They had received an average of 38 transfusions (range 3-107) from 65 donors (range 3-345). Twelve children were found positive for some marker of HBV: HBsAg in three (1.8%) and anti HBc in ten (7%). In 5 patients that had negative HBsAg and positive anti HBc, anti surface antigen antibodies (anti HBs) were determined and resulted positive in four Conclusions: The prevalence of HBV in this sample was 7% if both serologic markers are considered and 1.8% if only HBsAg is considered. |
| author |
Zubieta,Marcela Santolaya,María E Hurtado,Carmen Alvarez,Ana M Avilés,Carmen L Becker,Ana Brahm,Javier Salgado,Carmen Silva,Pamela Topelberg,Santiago Tordecilla,Juan Varas,Mónica Villarroel,Milena Viviani,Tamara |
| author_facet |
Zubieta,Marcela Santolaya,María E Hurtado,Carmen Alvarez,Ana M Avilés,Carmen L Becker,Ana Brahm,Javier Salgado,Carmen Silva,Pamela Topelberg,Santiago Tordecilla,Juan Varas,Mónica Villarroel,Milena Viviani,Tamara |
| author_sort |
Zubieta,Marcela |
| title |
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| title_short |
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| title_full |
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| title_fullStr |
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| title_full_unstemmed |
Seroprevalencia de virus hepatitis B en niños con cáncer en tratamiento quimioterápico en 6 hospitales de Santiago de Chile |
| title_sort |
seroprevalencia de virus hepatitis b en niños con cáncer en tratamiento quimioterápico en 6 hospitales de santiago de chile |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2009 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700007 |
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