Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test

Background: Rapidly growing mycobacteria (RGM) are considered opportunistic pathogens. An increasing number of post traumatic or surgical infections are caused by these microorganisms. Aim: To determine the antimicrobial susceptibility of RGM using the E-test method. Material and methods: A total of...

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Autores principales:	García-Agudo,Lidia, García-Martos,Pedro, Jesús,Iría, Rodríguez-Iglesias,Manuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Antibacterial agents Drug resistance, bacterial Mycobacteriaceae
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700008
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spelling	oai:scielo:S0034-988720090007000082010-04-29Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-testGarcía-Agudo,LidiaGarcía-Martos,PedroJesús,IríaRodríguez-Iglesias,Manuel Antibacterial agents Drug resistance, bacterial Mycobacteriaceae Background: Rapidly growing mycobacteria (RGM) are considered opportunistic pathogens. An increasing number of post traumatic or surgical infections are caused by these microorganisms. Aim: To determine the antimicrobial susceptibility of RGM using the E-test method. Material and methods: A total of 54 isolates of RGM was obtained from several clinical samples and selected for this study Strains were identified to the species level by phenotypic and biochemical characteristics, PCR-restriction enzyme analysis of the hsp65 gene (PRA) and sequencing of the 16S rRNA. Susceptibility was investigated by E-test to amikacin, cefoxitin, ciprofioxacin, clarithromycin, imipenem, quinupristin/dalfopristin, linezolid and tigecycline. Results: Twelve different species of RGM were identified: Mycobacterium fortuitum (23 strains), M chelonae (11), M abscessus (10), Msenegalense (2), Malvei (1), Mbrumae (1), Mmageritense (1), mucogenicum (1), M neoaurum (1), Mperegrinum (1), M septicum (1) y M smegmatis (1). All the strains were inhibited by low concentrations of amikacin and tigecycline. Susceptibility to cefoxitin, fluoroquinolones, clarithromycin, imipenem and linezolid was variable. All but two strains were resistant to quinupristin/ dalfopristin. Conclusions: Due to the uneven antimicrobial susceptibility of different species of RGM, an antimicrobial susceptibility test is mandatory for these microorganisms. The E-test method is well suited to determine minimum inhibitory concentrations.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.7 20092009-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700008es10.4067/S0034-98872009000700008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibacterial agents Drug resistance, bacterial Mycobacteriaceae
spellingShingle	Antibacterial agents Drug resistance, bacterial Mycobacteriaceae García-Agudo,Lidia García-Martos,Pedro Jesús,Iría Rodríguez-Iglesias,Manuel Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
description	Background: Rapidly growing mycobacteria (RGM) are considered opportunistic pathogens. An increasing number of post traumatic or surgical infections are caused by these microorganisms. Aim: To determine the antimicrobial susceptibility of RGM using the E-test method. Material and methods: A total of 54 isolates of RGM was obtained from several clinical samples and selected for this study Strains were identified to the species level by phenotypic and biochemical characteristics, PCR-restriction enzyme analysis of the hsp65 gene (PRA) and sequencing of the 16S rRNA. Susceptibility was investigated by E-test to amikacin, cefoxitin, ciprofioxacin, clarithromycin, imipenem, quinupristin/dalfopristin, linezolid and tigecycline. Results: Twelve different species of RGM were identified: Mycobacterium fortuitum (23 strains), M chelonae (11), M abscessus (10), Msenegalense (2), Malvei (1), Mbrumae (1), Mmageritense (1), mucogenicum (1), M neoaurum (1), Mperegrinum (1), M septicum (1) y M smegmatis (1). All the strains were inhibited by low concentrations of amikacin and tigecycline. Susceptibility to cefoxitin, fluoroquinolones, clarithromycin, imipenem and linezolid was variable. All but two strains were resistant to quinupristin/ dalfopristin. Conclusions: Due to the uneven antimicrobial susceptibility of different species of RGM, an antimicrobial susceptibility test is mandatory for these microorganisms. The E-test method is well suited to determine minimum inhibitory concentrations.
author	García-Agudo,Lidia García-Martos,Pedro Jesús,Iría Rodríguez-Iglesias,Manuel
author_facet	García-Agudo,Lidia García-Martos,Pedro Jesús,Iría Rodríguez-Iglesias,Manuel
author_sort	García-Agudo,Lidia
title	Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
title_short	Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
title_full	Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
title_fullStr	Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
title_full_unstemmed	Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test
title_sort	sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método e-test
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000700008
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Sensibilidad a los antimicrobianos de micobacterias de crecimiento rápido mediante el método E-test

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