Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos

Background: Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation. Aim To study the expression of p53 and p27 genes in subserosal gallbladder cancer. Material and methods: One hundred twenty seven tissue samples of subs...

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Autores principales:	Roa E,Iván, Lantadilla H,Soledad, Ibacache S,Gilda, de Aretxabala U,Xabier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Gallbladder neoplasms Genes p53 p27
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800003
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spelling	oai:scielo:S0034-988720090008000032009-11-04Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidosRoa E,IvánLantadilla H,SoledadIbacache S,Gildade Aretxabala U,Xabier Gallbladder neoplasms Genes p53 p27 Background: Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation. Aim To study the expression of p53 and p27 genes in subserosal gallbladder cancer. Material and methods: One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62 ± 13years and 15 men aged 67 ± 17years) and 50 control samples were selected to construct tissue arrays. p53 andp27genes were determined by immunohistochemistry. Results: Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p =0.05). No association between survival and p27 expression was observed. Conclusions: p53 gene expression is a prognostic factor for subserosal gallbladder cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.8 20092009-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800003es10.4067/S0034-98872009000800003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gallbladder neoplasms Genes p53 p27
spellingShingle	Gallbladder neoplasms Genes p53 p27 Roa E,Iván Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
description	Background: Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation. Aim To study the expression of p53 and p27 genes in subserosal gallbladder cancer. Material and methods: One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62 ± 13years and 15 men aged 67 ± 17years) and 50 control samples were selected to construct tissue arrays. p53 andp27genes were determined by immunohistochemistry. Results: Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p =0.05). No association between survival and p27 expression was observed. Conclusions: p53 gene expression is a prognostic factor for subserosal gallbladder cancer.
author	Roa E,Iván Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier
author_facet	Roa E,Iván Lantadilla H,Soledad Ibacache S,Gilda de Aretxabala U,Xabier
author_sort	Roa E,Iván
title	Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
title_short	Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
title_full	Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
title_fullStr	Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
title_full_unstemmed	Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
title_sort	carcinoma subseroso de la vesícula biliar (pt2): valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800003
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_version_	1718436457102704640

Carcinoma subseroso de la vesícula biliar (pT2): Valor pronóstico de la expresión de los genes supresores de tumores p53 y p27 en matrices de tejidos

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