Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar

Background: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts th...

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Autores principales:	Domínguez,José Miguel, Baudrand,René, Arteaga,Eugenio, Campusano,Claudia, González,Gilberto, Mosso,Lorena, Cavada,Gabriel, Cruz,Francisco, Torres,Javiera, Solar,Antonieta, Arias,Tatiana, Pizarro,Alejandra, Gómez,Marcelo, Fardella,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Biopsy fine-needle Carcinoma papillary Thyroid neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800005
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spelling	oai:scielo:S0034-988720090008000052009-11-04Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminarDomínguez,José MiguelBaudrand,RenéArteaga,EugenioCampusano,ClaudiaGonzález,GilbertoMosso,LorenaCavada,GabrielCruz,FranciscoTorres,JavieraSolar,AntonietaArias,TatianaPizarro,AlejandraGómez,MarceloFardella,Carlos Biopsy fine-needle Carcinoma papillary Thyroid neoplasms Background: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. Material and methods: Retrospective review of all fine needle aspiration biopsies of the thyroid performed in a lapse of two years. Biopsies that were conclusive for PTC were selected and compared with an equal amount of randomly selected biopsies that disclosed a benign diagnosis. Results: One hundred twenty two biopsies of a total of 1,498 were conclusive for PTC. Univariate analysis showed associations with PTC for the presence of micro-calcifications (Odds ratio (OR) 49.2: 95% confidence intervals (CI) 18.7-140.9), solid predominance (OR 25.1; 95% CI 6-220), hypoechogenicity (OR 23.5, 95% CI 6.5-122.6), irregular borders (OR 17, 95% CI 7.2-42.9), lymph node involvement (OR 12.3, 95% CI2.7-112), central vascularization (OR 12.2, 95% CI 4.8-33.3), local invasion and hyperechogenicity (OR 0.2; CI95% CI 0.03-0.6). Multivariate analysis disclosed microcalcifications (OR 28.1; CI 95% 8.9-89), hypoechogenicity (OR 9.4; 95% CI 1.5-59.5) and irregular borders (OR 4.7; CI 95% 1.5-15) as the variables independently associated with the presence of PTC. The prevalence of PTC in the presence of the three variables was 97.6% (Likelihood ratio (LR) 45) and 5.4% in their absence (LR 0.06). Conclusions: This scale predicts the presence or absence of PTC using simple ultrasound characteristics.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.8 20092009-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800005es10.4067/S0034-98872009000800005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Biopsy fine-needle Carcinoma papillary Thyroid neoplasms
spellingShingle	Biopsy fine-needle Carcinoma papillary Thyroid neoplasms Domínguez,José Miguel Baudrand,René Arteaga,Eugenio Campusano,Claudia González,Gilberto Mosso,Lorena Cavada,Gabriel Cruz,Francisco Torres,Javiera Solar,Antonieta Arias,Tatiana Pizarro,Alejandra Gómez,Marcelo Fardella,Carlos Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
description	Background: Thyroid nodules are common and associated to a low risk of malignancy. Their clinical assessment usually includes a fine neddle aspiration biopsy (FNAB). Aim To identify ultrasonographic characteristics associated to papillary thyroid carcinoma (PTC) and generate a score that predicts the risk of PTC. Material and methods: Retrospective review of all fine needle aspiration biopsies of the thyroid performed in a lapse of two years. Biopsies that were conclusive for PTC were selected and compared with an equal amount of randomly selected biopsies that disclosed a benign diagnosis. Results: One hundred twenty two biopsies of a total of 1,498 were conclusive for PTC. Univariate analysis showed associations with PTC for the presence of micro-calcifications (Odds ratio (OR) 49.2: 95% confidence intervals (CI) 18.7-140.9), solid predominance (OR 25.1; 95% CI 6-220), hypoechogenicity (OR 23.5, 95% CI 6.5-122.6), irregular borders (OR 17, 95% CI 7.2-42.9), lymph node involvement (OR 12.3, 95% CI2.7-112), central vascularization (OR 12.2, 95% CI 4.8-33.3), local invasion and hyperechogenicity (OR 0.2; CI95% CI 0.03-0.6). Multivariate analysis disclosed microcalcifications (OR 28.1; CI 95% 8.9-89), hypoechogenicity (OR 9.4; 95% CI 1.5-59.5) and irregular borders (OR 4.7; CI 95% 1.5-15) as the variables independently associated with the presence of PTC. The prevalence of PTC in the presence of the three variables was 97.6% (Likelihood ratio (LR) 45) and 5.4% in their absence (LR 0.06). Conclusions: This scale predicts the presence or absence of PTC using simple ultrasound characteristics.
author	Domínguez,José Miguel Baudrand,René Arteaga,Eugenio Campusano,Claudia González,Gilberto Mosso,Lorena Cavada,Gabriel Cruz,Francisco Torres,Javiera Solar,Antonieta Arias,Tatiana Pizarro,Alejandra Gómez,Marcelo Fardella,Carlos
author_facet	Domínguez,José Miguel Baudrand,René Arteaga,Eugenio Campusano,Claudia González,Gilberto Mosso,Lorena Cavada,Gabriel Cruz,Francisco Torres,Javiera Solar,Antonieta Arias,Tatiana Pizarro,Alejandra Gómez,Marcelo Fardella,Carlos
author_sort	Domínguez,José Miguel
title	Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
title_short	Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
title_full	Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
title_fullStr	Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
title_full_unstemmed	Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar
title_sort	diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: comunicación preliminar
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000800005
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Diseño de una escala ecográfica predictora de malignidad en nódulos tiroideos: Comunicación preliminar

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