Sistema hipocretinérgico y narcolepsia
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) sleep periods. It is now identified as a neurodegenerative disease because there is a massive loss of specific neurons in the brain. These neur...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2009
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oai:scielo:S0034-988720090009000122009-11-09Sistema hipocretinérgico y narcolepsiaArias-Carrión,Oscar Hypocretin-1 human Narcolepsy Sleep Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) sleep periods. It is now identified as a neurodegenerative disease because there is a massive loss of specific neurons in the brain. These neurons contain the neuropeptides hypocretin-1 and hypocretin-2, which are also known as orexin-A and orexin-B. Cerebrospinal fluid hypocretin-1 measurements are diagnostic for primary narcolepsy. The cause of neural loss could be autoinmune since most patients have the HLA DQB1*0602 alíele that predisposes to the disorders. The discovery of hypocretin deficiency is redefining the clinical entity of narcolepsy and offering novel diagnostic procedures. This article reviews the current understanding of narcolepsy and discusses the implications of hypocretin discovery (Rev Méd Chile 2009; 137:1209-16).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.9 20092009-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000900012es10.4067/S0034-98872009000900012 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Hypocretin-1 human Narcolepsy Sleep |
| spellingShingle |
Hypocretin-1 human Narcolepsy Sleep Arias-Carrión,Oscar Sistema hipocretinérgico y narcolepsia |
| description |
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, and sleep-onset rapid eye movement (REM) sleep periods. It is now identified as a neurodegenerative disease because there is a massive loss of specific neurons in the brain. These neurons contain the neuropeptides hypocretin-1 and hypocretin-2, which are also known as orexin-A and orexin-B. Cerebrospinal fluid hypocretin-1 measurements are diagnostic for primary narcolepsy. The cause of neural loss could be autoinmune since most patients have the HLA DQB1*0602 alíele that predisposes to the disorders. The discovery of hypocretin deficiency is redefining the clinical entity of narcolepsy and offering novel diagnostic procedures. This article reviews the current understanding of narcolepsy and discusses the implications of hypocretin discovery (Rev Méd Chile 2009; 137:1209-16). |
| author |
Arias-Carrión,Oscar |
| author_facet |
Arias-Carrión,Oscar |
| author_sort |
Arias-Carrión,Oscar |
| title |
Sistema hipocretinérgico y narcolepsia |
| title_short |
Sistema hipocretinérgico y narcolepsia |
| title_full |
Sistema hipocretinérgico y narcolepsia |
| title_fullStr |
Sistema hipocretinérgico y narcolepsia |
| title_full_unstemmed |
Sistema hipocretinérgico y narcolepsia |
| title_sort |
sistema hipocretinérgico y narcolepsia |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2009 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000900012 |
| work_keys_str_mv |
AT ariascarrionoscar sistemahipocretinergicoynarcolepsia |
| _version_ |
1718436465190371328 |