Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia

Background: Helicobacter pylori antimicrobial resistance rates differ among countries and even between different areas of a country. In Colombia, the most commonly used antimicrobials for the treatment of H pylori infection are amoxicillin, clarithromycin and metronidazole. Aim: To determine antimic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Álvarez,Adalucy, Moncayo,José Ignacio, Santacruz,Jorge Javier, Corredor,Luisa Fernanda, Reinosa,Elizabeth, Martínez,José William, Beltrán,Leonardo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Antibacterial agents Helicobacter pylori Metronidazole
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000005
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872009001000005
record_format	dspace
spelling	oai:scielo:S0034-988720090010000052009-12-02Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en ColombiaÁlvarez,AdalucyMoncayo,José IgnacioSantacruz,Jorge JavierCorredor,Luisa FernandaReinosa,ElizabethMartínez,José WilliamBeltrán,Leonardo Antibacterial agents Helicobacter pylori Metronidazole Background: Helicobacter pylori antimicrobial resistance rates differ among countries and even between different areas of a country. In Colombia, the most commonly used antimicrobials for the treatment of H pylori infection are amoxicillin, clarithromycin and metronidazole. Aim: To determine antimicrobial susceptibility of H pylori strains isolated in Colombia. Materials and methods: Eighty eight strains of H pylori were isolated and identified by microbiological methods and confirmed with polymerase chain reaction (PCR). The detection of antimicrobial resistance to amoxicillin, clarithromycin, metronidazole and tetraclycline, was conducted by the Etest method. Mutations in the 23S rDNA, involved in resistance to clarithromycin, were detected using PCR and restriction fragment lenght polymorphism. Results: Eighty eight and 2.2% of the strains were resistant to metronidazole and clarithromycin, respectively. No isolate was simultaneously resistant to amoxicillin or tetracycline. The two clarithromycin resistant strains were homozygous for the A2143G mutation. No mutations were found in the remaining 86 susceptible strains. Conclusions: The high rate of metronidazole resistance in our population precludes the use of this drug for the empirical treatment of Hpylori infection.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.10 20092009-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000005es10.4067/S0034-98872009001000005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibacterial agents Helicobacter pylori Metronidazole
spellingShingle	Antibacterial agents Helicobacter pylori Metronidazole Álvarez,Adalucy Moncayo,José Ignacio Santacruz,Jorge Javier Corredor,Luisa Fernanda Reinosa,Elizabeth Martínez,José William Beltrán,Leonardo Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
description	Background: Helicobacter pylori antimicrobial resistance rates differ among countries and even between different areas of a country. In Colombia, the most commonly used antimicrobials for the treatment of H pylori infection are amoxicillin, clarithromycin and metronidazole. Aim: To determine antimicrobial susceptibility of H pylori strains isolated in Colombia. Materials and methods: Eighty eight strains of H pylori were isolated and identified by microbiological methods and confirmed with polymerase chain reaction (PCR). The detection of antimicrobial resistance to amoxicillin, clarithromycin, metronidazole and tetraclycline, was conducted by the Etest method. Mutations in the 23S rDNA, involved in resistance to clarithromycin, were detected using PCR and restriction fragment lenght polymorphism. Results: Eighty eight and 2.2% of the strains were resistant to metronidazole and clarithromycin, respectively. No isolate was simultaneously resistant to amoxicillin or tetracycline. The two clarithromycin resistant strains were homozygous for the A2143G mutation. No mutations were found in the remaining 86 susceptible strains. Conclusions: The high rate of metronidazole resistance in our population precludes the use of this drug for the empirical treatment of Hpylori infection.
author	Álvarez,Adalucy Moncayo,José Ignacio Santacruz,Jorge Javier Corredor,Luisa Fernanda Reinosa,Elizabeth Martínez,José William Beltrán,Leonardo
author_facet	Álvarez,Adalucy Moncayo,José Ignacio Santacruz,Jorge Javier Corredor,Luisa Fernanda Reinosa,Elizabeth Martínez,José William Beltrán,Leonardo
author_sort	Álvarez,Adalucy
title	Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
title_short	Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
title_full	Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
title_fullStr	Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
title_full_unstemmed	Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia
title_sort	resistencia a metronidazol y claritromicina en aislamientos de helicobacter pylori de pacientes dispépticos en colombia
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000005
work_keys_str_mv	AT alvarezadalucy resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT moncayojoseignacio resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT santacruzjorgejavier resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT corredorluisafernanda resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT reinosaelizabeth resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT martinezjosewilliam resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia AT beltranleonardo resistenciaametronidazolyclaritromicinaenaislamientosdehelicobacterpyloridepacientesdispepticosencolombia
_version_	1718436468124286976

Resistencia a metronidazol y claritromicina en aislamientos de Helicobacter pylori de pacientes dispépticos en Colombia

Ejemplares similares