Infecciones en pacientes con lupus eritematoso sistémico

Despite the availability of newer therapeutic interventions to improve clinical outcome in patients with Systemic Lupus Erythematosus (SLE), the incidence of infections as a cause of morbidity and mortality has not changed over the past 30 years. SLE itself increases the risk of infection, due to ge...

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Autores principales:	Enberg G,Margarita, Kahn Ch,Mariana, Goity F,Cecilia, Villalón S,María Valentina, Zamorano R,Juanita, Figueroa E,Fernando
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Complement system proteins Lupus erythematosus systemic Opportunistic infections
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000014
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spelling	oai:scielo:S0034-988720090010000142009-12-02Infecciones en pacientes con lupus eritematoso sistémicoEnberg G,MargaritaKahn Ch,MarianaGoity F,CeciliaVillalón S,María ValentinaZamorano R,JuanitaFigueroa E,Fernando Complement system proteins Lupus erythematosus systemic Opportunistic infections Despite the availability of newer therapeutic interventions to improve clinical outcome in patients with Systemic Lupus Erythematosus (SLE), the incidence of infections as a cause of morbidity and mortality has not changed over the past 30 years. SLE itself increases the risk of infection, due to genetic (complement deficiencies) and acquired factors such as functional asplenia (humoral immunodepression) and the use of immunosuppressive drugs. These medications increase the risk of opportunistic infections that are associated with an altered cellular immune response. The main etiologic infectious agents in SLE patients are common bacterial pathogens, especially capsulated ones. The most common sites are lung, skin, bladder, brain and systemic infections. The main risk factor for infection is the history of a previous one. The clinical approach to SLE patients with suspected infectious diseases must consider the possibility of a flare up of the underlying disease, posing an additional problem to the clinician.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.10 20092009-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000014es10.4067/S0034-98872009001000014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Complement system proteins Lupus erythematosus systemic Opportunistic infections
spellingShingle	Complement system proteins Lupus erythematosus systemic Opportunistic infections Enberg G,Margarita Kahn Ch,Mariana Goity F,Cecilia Villalón S,María Valentina Zamorano R,Juanita Figueroa E,Fernando Infecciones en pacientes con lupus eritematoso sistémico
description	Despite the availability of newer therapeutic interventions to improve clinical outcome in patients with Systemic Lupus Erythematosus (SLE), the incidence of infections as a cause of morbidity and mortality has not changed over the past 30 years. SLE itself increases the risk of infection, due to genetic (complement deficiencies) and acquired factors such as functional asplenia (humoral immunodepression) and the use of immunosuppressive drugs. These medications increase the risk of opportunistic infections that are associated with an altered cellular immune response. The main etiologic infectious agents in SLE patients are common bacterial pathogens, especially capsulated ones. The most common sites are lung, skin, bladder, brain and systemic infections. The main risk factor for infection is the history of a previous one. The clinical approach to SLE patients with suspected infectious diseases must consider the possibility of a flare up of the underlying disease, posing an additional problem to the clinician.
author	Enberg G,Margarita Kahn Ch,Mariana Goity F,Cecilia Villalón S,María Valentina Zamorano R,Juanita Figueroa E,Fernando
author_facet	Enberg G,Margarita Kahn Ch,Mariana Goity F,Cecilia Villalón S,María Valentina Zamorano R,Juanita Figueroa E,Fernando
author_sort	Enberg G,Margarita
title	Infecciones en pacientes con lupus eritematoso sistémico
title_short	Infecciones en pacientes con lupus eritematoso sistémico
title_full	Infecciones en pacientes con lupus eritematoso sistémico
title_fullStr	Infecciones en pacientes con lupus eritematoso sistémico
title_full_unstemmed	Infecciones en pacientes con lupus eritematoso sistémico
title_sort	infecciones en pacientes con lupus eritematoso sistémico
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000014
work_keys_str_mv	AT enberggmargarita infeccionesenpacientesconlupuseritematososistemico AT kahnchmariana infeccionesenpacientesconlupuseritematososistemico AT goityfcecilia infeccionesenpacientesconlupuseritematososistemico AT villalonsmariavalentina infeccionesenpacientesconlupuseritematososistemico AT zamoranorjuanita infeccionesenpacientesconlupuseritematososistemico AT figueroaefernando infeccionesenpacientesconlupuseritematososistemico
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Infecciones en pacientes con lupus eritematoso sistémico

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