Fisiopatología de la retinopatía y nefropatía diabéticas

Despite the availability of multiple therapeutic approaches, diabetes mellitus with chronic hyperglycemia remains as the main cause of new cases of blindness and chronic renal failure in the western hemisphere. We herein review the molecular mechanisms by which chronic hyperglycemia causes retinopat...

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Autores principales:	Olmos,Pablo, Araya-Del-Pino,Andrea, González,Cristián, Laso,Pablo, Irribarra,Verónica, Rubio,Lorena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Diabetes mellitus Diabetic nephropathy Diabetic retinopathy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000015
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spelling	oai:scielo:S0034-988720090010000152009-12-02Fisiopatología de la retinopatía y nefropatía diabéticasOlmos,PabloAraya-Del-Pino,AndreaGonzález,CristiánLaso,PabloIrribarra,VerónicaRubio,Lorena Diabetes mellitus Diabetic nephropathy Diabetic retinopathy Despite the availability of multiple therapeutic approaches, diabetes mellitus with chronic hyperglycemia remains as the main cause of new cases of blindness and chronic renal failure in the western hemisphere. We herein review the molecular mechanisms by which chronic hyperglycemia causes retinopathy and nephropathy in type I and type 2 diabetic patients. Diabetic retinopathy develops silently along years or decades, producing symptoms only in its very ¡ate stages. Its slow development starts with the activation of aldose reducíase, shortly followed by the destruction of the retinal pericyte cells, and ends in sudden blindness when vitreous hemorrhage ensues. Nephropathy, on the other hand, centers its pathophysiology in the mesangial cell, that starts as a modified smooth-muscle cell, and turns itself into a myo-fibroblast, produces such amounts of cytoplasm and extracellular protein that strangulates the glomerular capillaries and causes renal failure. After a detailed review of the molecular mechanisms of the aforementioned complications, we conclude that, apart from directing our attention to the emerging medications that are being developed to block these molecular pathways, we should never abandon the struggle for improving the glycemic control of our diabetic patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.10 20092009-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000015es10.4067/S0034-98872009001000015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus Diabetic nephropathy Diabetic retinopathy
spellingShingle	Diabetes mellitus Diabetic nephropathy Diabetic retinopathy Olmos,Pablo Araya-Del-Pino,Andrea González,Cristián Laso,Pablo Irribarra,Verónica Rubio,Lorena Fisiopatología de la retinopatía y nefropatía diabéticas
description	Despite the availability of multiple therapeutic approaches, diabetes mellitus with chronic hyperglycemia remains as the main cause of new cases of blindness and chronic renal failure in the western hemisphere. We herein review the molecular mechanisms by which chronic hyperglycemia causes retinopathy and nephropathy in type I and type 2 diabetic patients. Diabetic retinopathy develops silently along years or decades, producing symptoms only in its very ¡ate stages. Its slow development starts with the activation of aldose reducíase, shortly followed by the destruction of the retinal pericyte cells, and ends in sudden blindness when vitreous hemorrhage ensues. Nephropathy, on the other hand, centers its pathophysiology in the mesangial cell, that starts as a modified smooth-muscle cell, and turns itself into a myo-fibroblast, produces such amounts of cytoplasm and extracellular protein that strangulates the glomerular capillaries and causes renal failure. After a detailed review of the molecular mechanisms of the aforementioned complications, we conclude that, apart from directing our attention to the emerging medications that are being developed to block these molecular pathways, we should never abandon the struggle for improving the glycemic control of our diabetic patients.
author	Olmos,Pablo Araya-Del-Pino,Andrea González,Cristián Laso,Pablo Irribarra,Verónica Rubio,Lorena
author_facet	Olmos,Pablo Araya-Del-Pino,Andrea González,Cristián Laso,Pablo Irribarra,Verónica Rubio,Lorena
author_sort	Olmos,Pablo
title	Fisiopatología de la retinopatía y nefropatía diabéticas
title_short	Fisiopatología de la retinopatía y nefropatía diabéticas
title_full	Fisiopatología de la retinopatía y nefropatía diabéticas
title_fullStr	Fisiopatología de la retinopatía y nefropatía diabéticas
title_full_unstemmed	Fisiopatología de la retinopatía y nefropatía diabéticas
title_sort	fisiopatología de la retinopatía y nefropatía diabéticas
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001000015
work_keys_str_mv	AT olmospablo fisiopatologiadelaretinopatiaynefropatiadiabeticas AT arayadelpinoandrea fisiopatologiadelaretinopatiaynefropatiadiabeticas AT gonzalezcristian fisiopatologiadelaretinopatiaynefropatiadiabeticas AT lasopablo fisiopatologiadelaretinopatiaynefropatiadiabeticas AT irribarraveronica fisiopatologiadelaretinopatiaynefropatiadiabeticas AT rubiolorena fisiopatologiadelaretinopatiaynefropatiadiabeticas
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Fisiopatología de la retinopatía y nefropatía diabéticas

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