Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis

Atypical antipsychotic drugs have less extra pyramidal side effects and are more effective to control the clinical manifestations of schizophrenia. However, their use may be associated to a higher incidence of weight gain, dyslipidemia, metabolic syndrome, glucose intolerance and type 2 diabetes mel...

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Autores principales:	Sapunar Z,Jorge, Muñoz N,Sergio, Vásquez A,Tatiana
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Antipsychotic agents Aripiprazole Diabetes mellitus Clozapine Olanzapine Quetiapine Risperidone Ziprasidone Zotepine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100002
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spelling	oai:scielo:S0034-988720090011000022010-01-13Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisisSapunar Z,JorgeMuñoz N,SergioVásquez A,Tatiana Antipsychotic agents Aripiprazole Diabetes mellitus Clozapine Olanzapine Quetiapine Risperidone Ziprasidone Zotepine Atypical antipsychotic drugs have less extra pyramidal side effects and are more effective to control the clinical manifestations of schizophrenia. However, their use may be associated to a higher incidence of weight gain, dyslipidemia, metabolic syndrome, glucose intolerance and type 2 diabetes mellitus. We performed a systematic literature search to evaluate the risk of type 2 diabetes mellitus incidence associated to the use of atypical antipsychotic drugs, compared to conventional treatment. If users of all types of atypical antipsychotic drugs are compared with users of conventional treatment, no significant differences in the incidence of type 2 diabetes mellitus were observed. If individual drugs are evaluated, clozapine and risperidone are associated with a higher risk of diabetes than haloperidol. Quetiapine is associated with a lower risk of diabetes than conventional treatment. The quality of the evidence found was low; therefore, new studies should been performed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.11 20092009-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100002es10.4067/S0034-98872009001100002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antipsychotic agents Aripiprazole Diabetes mellitus Clozapine Olanzapine Quetiapine Risperidone Ziprasidone Zotepine
spellingShingle	Antipsychotic agents Aripiprazole Diabetes mellitus Clozapine Olanzapine Quetiapine Risperidone Ziprasidone Zotepine Sapunar Z,Jorge Muñoz N,Sergio Vásquez A,Tatiana Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
description	Atypical antipsychotic drugs have less extra pyramidal side effects and are more effective to control the clinical manifestations of schizophrenia. However, their use may be associated to a higher incidence of weight gain, dyslipidemia, metabolic syndrome, glucose intolerance and type 2 diabetes mellitus. We performed a systematic literature search to evaluate the risk of type 2 diabetes mellitus incidence associated to the use of atypical antipsychotic drugs, compared to conventional treatment. If users of all types of atypical antipsychotic drugs are compared with users of conventional treatment, no significant differences in the incidence of type 2 diabetes mellitus were observed. If individual drugs are evaluated, clozapine and risperidone are associated with a higher risk of diabetes than haloperidol. Quetiapine is associated with a lower risk of diabetes than conventional treatment. The quality of the evidence found was low; therefore, new studies should been performed.
author	Sapunar Z,Jorge Muñoz N,Sergio Vásquez A,Tatiana
author_facet	Sapunar Z,Jorge Muñoz N,Sergio Vásquez A,Tatiana
author_sort	Sapunar Z,Jorge
title	Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
title_short	Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
title_full	Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
title_fullStr	Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
title_full_unstemmed	Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis
title_sort	comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: revisión sistemática y metaanálisis
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100002
work_keys_str_mv	AT sapunarzjorge comparaciondelefectodelaterapiaprolongadaconantipsicoticosatipicosoconvencionalesenlaincidenciadediabetesmellitus2revisionsistematicaymetaanalisis AT munoznsergio comparaciondelefectodelaterapiaprolongadaconantipsicoticosatipicosoconvencionalesenlaincidenciadediabetesmellitus2revisionsistematicaymetaanalisis AT vasquezatatiana comparaciondelefectodelaterapiaprolongadaconantipsicoticosatipicosoconvencionalesenlaincidenciadediabetesmellitus2revisionsistematicaymetaanalisis
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Comparación del efecto de la terapia prolongada con antipsicóticos atípicos o convencionales en la incidencia de diabetes mellitus 2: Revisión sistemática y metaanálisis

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