Enfermedad celíaca y su patogenia

Enfermedad celíaca y su patogenia

Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy,...

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Autores principales: Herrera,María José, Hermoso,Marcela A, Quera,Rodrigo
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2009
Materias:
Celiac disease, Gliadin
HLA-D antigens
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001200012
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spelling oai:scielo:S0034-988720090012000122010-05-24Enfermedad celíaca y su patogeniaHerrera,María JoséHermoso,Marcela AQuera,Rodrigo Celiac disease, Gliadin HLA-D antigens Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis (IELs) and leukocyte infiltration of the lamina propriety. Patients achieve a complete clinical and endoscopic remission with a gluten free diet. However, symptoms and anatomical alterations recur when this protein is reintroduced in the diet. The pathogenic mechanisms in this disease are not yet well understood, but it is clear that genetic, environmental and immunological factors play a role. The latter are the focus of this review, since this is the only autoimmune disease whose precipitating factor for immunological tissue damage is known.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.12 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001200012es10.4067/S0034-98872009001200012
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Celiac disease, Gliadin
HLA-D antigens
spellingShingle Celiac disease, Gliadin
HLA-D antigens
Herrera,María José
Hermoso,Marcela A
Quera,Rodrigo
Enfermedad celíaca y su patogenia
description Celiac disease (CD), with a 1% worldwide prevalence, is an enteropathy caused by an autoimmune reaction to gluten in genetically susceptible individuals, which codify for histocompatibility molecules HLA DQ-2/DQ-8. From the anatomical point of view, CD is characterized by intestinal villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis (IELs) and leukocyte infiltration of the lamina propriety. Patients achieve a complete clinical and endoscopic remission with a gluten free diet. However, symptoms and anatomical alterations recur when this protein is reintroduced in the diet. The pathogenic mechanisms in this disease are not yet well understood, but it is clear that genetic, environmental and immunological factors play a role. The latter are the focus of this review, since this is the only autoimmune disease whose precipitating factor for immunological tissue damage is known.
author Herrera,María José
Hermoso,Marcela A
Quera,Rodrigo
author_facet Herrera,María José
Hermoso,Marcela A
Quera,Rodrigo
author_sort Herrera,María José
title Enfermedad celíaca y su patogenia
title_short Enfermedad celíaca y su patogenia
title_full Enfermedad celíaca y su patogenia
title_fullStr Enfermedad celíaca y su patogenia
title_full_unstemmed Enfermedad celíaca y su patogenia
title_sort enfermedad celíaca y su patogenia
publisher Sociedad Médica de Santiago
publishDate 2009
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001200012
work_keys_str_mv AT herreramariajose enfermedadceliacaysupatogenia
AT hermosomarcelaa enfermedadceliacaysupatogenia
AT querarodrigo enfermedadceliacaysupatogenia
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