Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata

Syndecans, a family of heparan sulphate proteoglycans that are present in the cellsurface are involved in the control o fcel lproliferation, apoptosis and transfor-mation. Syndecans 1 and 2 have a central role in processes such as position control, invasion, angiogenesis and metastases ofseveral typ...

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Autor principal:	CONTRERAS,HÉCTOR R
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Neoplasm invasiveness Prostatic neoplasms Proteoglycans
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000100014
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spelling	oai:scielo:S0034-988720100001000142010-05-10Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstataCONTRERAS,HÉCTOR R Neoplasm invasiveness Prostatic neoplasms Proteoglycans Syndecans, a family of heparan sulphate proteoglycans that are present in the cellsurface are involved in the control o fcel lproliferation, apoptosis and transfor-mation. Syndecans 1 and 2 have a central role in processes such as position control, invasion, angiogenesis and metastases ofseveral types of cáncer The expression of Syndecan 1 in epithelial cells, decreases when cells are transformed and acquire invasive properties. This decreased expression is associated to a bad prognosis. Syndecan 2, originally described in mesenchymal cells, favors cell apoptosis, increa-ses angiogenesis and controls the death of cáncer cells subjected to chemotherapy Both syndecans are present in basal and epithelial cells of prostate cancer Their lower expression is associated to more undifferentiated tumors. Disturbances in the expression and subcellular location of syndecans predict the relapse of localized tumors. Syndecans 1 and 2 can be considered tumor suppression genes and can be targetsfor new treatments. The detection of circulating fragments of these molecules could be useful for the early detection of prostate cancer.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.1 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000100014es10.4067/S0034-98872010000100014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Neoplasm invasiveness Prostatic neoplasms Proteoglycans
spellingShingle	Neoplasm invasiveness Prostatic neoplasms Proteoglycans CONTRERAS,HÉCTOR R Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
description	Syndecans, a family of heparan sulphate proteoglycans that are present in the cellsurface are involved in the control o fcel lproliferation, apoptosis and transfor-mation. Syndecans 1 and 2 have a central role in processes such as position control, invasion, angiogenesis and metastases ofseveral types of cáncer The expression of Syndecan 1 in epithelial cells, decreases when cells are transformed and acquire invasive properties. This decreased expression is associated to a bad prognosis. Syndecan 2, originally described in mesenchymal cells, favors cell apoptosis, increa-ses angiogenesis and controls the death of cáncer cells subjected to chemotherapy Both syndecans are present in basal and epithelial cells of prostate cancer Their lower expression is associated to more undifferentiated tumors. Disturbances in the expression and subcellular location of syndecans predict the relapse of localized tumors. Syndecans 1 and 2 can be considered tumor suppression genes and can be targetsfor new treatments. The detection of circulating fragments of these molecules could be useful for the early detection of prostate cancer.
author	CONTRERAS,HÉCTOR R
author_facet	CONTRERAS,HÉCTOR R
author_sort	CONTRERAS,HÉCTOR R
title	Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
title_short	Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
title_full	Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
title_fullStr	Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
title_full_unstemmed	Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata
title_sort	sindecanos: su potencial uso diagnóstico y pronóstico en cáncer de próstata
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000100014
work_keys_str_mv	AT contrerashectorr sindecanossupotencialusodiagnosticoypronosticoencancerdeprostata
_version_	1718436484994826240

Sindecanos: Su potencial uso diagnóstico y pronóstico en cáncer de próstata

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