Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile

Background: Salivary cortisol measurement is recommended as a screening mea-sure when a Cushing Syndrome is suspected. Theproposed cut-offpointfor aprobable diagnosis is 0.16 ug/dL. Aim: To determine salivary cortisol concentrations during the day inpatients with and without Cushing syndrome and wit...

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Autores principales:	LÉPEZ,MACARENA, CAAMAÑO,EGARDO, ROMERO,CARMEN, FIEDLER,JENNY, ARAYA,VERÓNICA
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Cushing syndrome Hydrocortisone Saliva
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000200004
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spelling	oai:scielo:S0034-988720100002000042010-03-30Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de ChileLÉPEZ,MACARENACAAMAÑO,EGARDOROMERO,CARMENFIEDLER,JENNYARAYA,VERÓNICA Cushing syndrome Hydrocortisone Saliva Background: Salivary cortisol measurement is recommended as a screening mea-sure when a Cushing Syndrome is suspected. Theproposed cut-offpointfor aprobable diagnosis is 0.16 ug/dL. Aim: To determine salivary cortisol concentrations during the day inpatients with and without Cushing syndrome and with depression. Material and Methods: Salivary cortisol was measured by competitive enzyme immuno assay (EIA), in samples obtained at 8:00,15:00 and 23:00 h in 78 patients without Cushing syndrome, aged 40 ± 15years (28 males), 30 patients with depression aged 40 ± 12years (nine males) and four jemales with Cushing syndrome aged 42 ± 17 years. Results: Salivary cortisol was higher among patients with Cushing syndrome than the rest of patients. A salivary cortisol over the cut-off value of O.16 ug/dL was found in 42% of subjects without Cushing syndrome and in 33% of patients with depression. Median values among patients without Cushing syndrome, depression and with Cushing syndrome were 0.21 (range < 0.1-1.42), 0.2 (range 0,12-0.9) and 0.58 (range 0.37-1.1) ug/dL, respectively Conclusions: Salivary cortisol measured by EIA method was higher among patients with Cushing syndrome but there was a great overlap with values obtained in subjects without the syndrome.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.2 20102010-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000200004es10.4067/S0034-98872010000200004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cushing syndrome Hydrocortisone Saliva
spellingShingle	Cushing syndrome Hydrocortisone Saliva LÉPEZ,MACARENA CAAMAÑO,EGARDO ROMERO,CARMEN FIEDLER,JENNY ARAYA,VERÓNICA Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
description	Background: Salivary cortisol measurement is recommended as a screening mea-sure when a Cushing Syndrome is suspected. Theproposed cut-offpointfor aprobable diagnosis is 0.16 ug/dL. Aim: To determine salivary cortisol concentrations during the day inpatients with and without Cushing syndrome and with depression. Material and Methods: Salivary cortisol was measured by competitive enzyme immuno assay (EIA), in samples obtained at 8:00,15:00 and 23:00 h in 78 patients without Cushing syndrome, aged 40 ± 15years (28 males), 30 patients with depression aged 40 ± 12years (nine males) and four jemales with Cushing syndrome aged 42 ± 17 years. Results: Salivary cortisol was higher among patients with Cushing syndrome than the rest of patients. A salivary cortisol over the cut-off value of O.16 ug/dL was found in 42% of subjects without Cushing syndrome and in 33% of patients with depression. Median values among patients without Cushing syndrome, depression and with Cushing syndrome were 0.21 (range < 0.1-1.42), 0.2 (range 0,12-0.9) and 0.58 (range 0.37-1.1) ug/dL, respectively Conclusions: Salivary cortisol measured by EIA method was higher among patients with Cushing syndrome but there was a great overlap with values obtained in subjects without the syndrome.
author	LÉPEZ,MACARENA CAAMAÑO,EGARDO ROMERO,CARMEN FIEDLER,JENNY ARAYA,VERÓNICA
author_facet	LÉPEZ,MACARENA CAAMAÑO,EGARDO ROMERO,CARMEN FIEDLER,JENNY ARAYA,VERÓNICA
author_sort	LÉPEZ,MACARENA
title	Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
title_short	Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
title_full	Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
title_fullStr	Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
title_full_unstemmed	Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile
title_sort	determinación de los niveles de cortisol salival en una muestra de sujetos de santiago de chile
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000200004
work_keys_str_mv	AT lepezmacarena determinaciondelosnivelesdecortisolsalivalenunamuestradesujetosdesantiagodechile AT caamanoegardo determinaciondelosnivelesdecortisolsalivalenunamuestradesujetosdesantiagodechile AT romerocarmen determinaciondelosnivelesdecortisolsalivalenunamuestradesujetosdesantiagodechile AT fiedlerjenny determinaciondelosnivelesdecortisolsalivalenunamuestradesujetosdesantiagodechile AT arayaveronica determinaciondelosnivelesdecortisolsalivalenunamuestradesujetosdesantiagodechile
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Determinación de los niveles de cortisol salival en una muestra de sujetos de Santiago de Chile

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