Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos

Background: Eleven percent of hospitalized patients experience drug-drug interactions (DDIs), elevating morbidity, mortality and health care costs. Polypharmacy is very common in intensive care units (ICUs), increasing the risks of drug adverse events (AEs). Aim: To assess DDIs in ICU patients. Mate...

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Autores principales:	PLAZA,JULIO, ÁLAMO,MAURICIO, TORRES,PAULINA, FUENTES,ÁLVARO, LÓPEZ,FERNANDO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Drug interactions Intensive care units Polypharmacy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400009
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spelling	oai:scielo:S0034-988720100004000092010-06-30Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivosPLAZA,JULIOÁLAMO,MAURICIOTORRES,PAULINAFUENTES,ÁLVAROLÓPEZ,FERNANDO Drug interactions Intensive care units Polypharmacy Background: Eleven percent of hospitalized patients experience drug-drug interactions (DDIs), elevating morbidity, mortality and health care costs. Polypharmacy is very common in intensive care units (ICUs), increasing the risks of drug adverse events (AEs). Aim: To assess DDIs in ICU patients. Material and Methods: A prospective study conducted in the ICU of a private hospital, evaluating the frequency of DDIs, AEs developed and their relationship. Patients admitted to the ICU were included if they stayed at least three days in the ICU and received at least one studied drug Results: Thirty fve patients aged 59 ± 16 years (24 women) were enrolled in the study. Seventy six DDIs and 60 AEs were recorded. Statistically signifcant associations were only found for midazolam-fentanyl-propofol with bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin with acute renal failure (ARF). Relative risks were 10.4 (95% confdence intervals (CI) 1.59 - 68) for bradicardia, 5 (95% CI 1.082 - 23.4) for hypotension and 6.4 (95% CI 1.9 - 21.6) for ARF. The odds ratios were 125.2 (95% CI 3 - 250), 12.6 (95% CI 1.3 - 77) and 10.8 (95% CI 1.3 - 282) respectively. Conclusions: DDIs associated with risk of AEs were fentanyl, propofol and midazolam for bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin for ARF.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.4 20102010-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400009es10.4067/S0034-98872010000400009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug interactions Intensive care units Polypharmacy
spellingShingle	Drug interactions Intensive care units Polypharmacy PLAZA,JULIO ÁLAMO,MAURICIO TORRES,PAULINA FUENTES,ÁLVARO LÓPEZ,FERNANDO Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
description	Background: Eleven percent of hospitalized patients experience drug-drug interactions (DDIs), elevating morbidity, mortality and health care costs. Polypharmacy is very common in intensive care units (ICUs), increasing the risks of drug adverse events (AEs). Aim: To assess DDIs in ICU patients. Material and Methods: A prospective study conducted in the ICU of a private hospital, evaluating the frequency of DDIs, AEs developed and their relationship. Patients admitted to the ICU were included if they stayed at least three days in the ICU and received at least one studied drug Results: Thirty fve patients aged 59 ± 16 years (24 women) were enrolled in the study. Seventy six DDIs and 60 AEs were recorded. Statistically signifcant associations were only found for midazolam-fentanyl-propofol with bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin with acute renal failure (ARF). Relative risks were 10.4 (95% confdence intervals (CI) 1.59 - 68) for bradicardia, 5 (95% CI 1.082 - 23.4) for hypotension and 6.4 (95% CI 1.9 - 21.6) for ARF. The odds ratios were 125.2 (95% CI 3 - 250), 12.6 (95% CI 1.3 - 77) and 10.8 (95% CI 1.3 - 282) respectively. Conclusions: DDIs associated with risk of AEs were fentanyl, propofol and midazolam for bradycardia and hypotension and amphotericin B-vancomycin and vancomycin-amikacin for ARF.
author	PLAZA,JULIO ÁLAMO,MAURICIO TORRES,PAULINA FUENTES,ÁLVARO LÓPEZ,FERNANDO
author_facet	PLAZA,JULIO ÁLAMO,MAURICIO TORRES,PAULINA FUENTES,ÁLVARO LÓPEZ,FERNANDO
author_sort	PLAZA,JULIO
title	Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
title_short	Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
title_full	Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
title_fullStr	Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
title_full_unstemmed	Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
title_sort	interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400009
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Interacciones de medicamentos y eventos adversos en fármacos utilizados en una unidad de cuidados intensivos

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