Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico

The nervous system is affected in 10% of patients with sarcoidosis. However, neurological disturbances are rarely the frst manifestation of the disease. We report a 36-year-old woman presenting with partial seizures that generalized secondarily. Magnetic resonance showed a left parietal cortical-sub...

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Autores principales:	FERNÁNDEZ-REY,CRISTINA LIDIA, SAIZ AYALA,ANTONIO, ÁLVAREZ-URÍA TEJERO,MARÍA JESÚS, SANTAMARTA LIÉBANA,ELENA, COSTILLA GARCÍA,SERAFÍN
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Peptidyl-dipeptidase A Sarcoidosis Seizures
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400012
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spelling	oai:scielo:S0034-988720100004000122010-06-30Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínicoFERNÁNDEZ-REY,CRISTINA LIDIASAIZ AYALA,ANTONIOÁLVAREZ-URÍA TEJERO,MARÍA JESÚSSANTAMARTA LIÉBANA,ELENACOSTILLA GARCÍA,SERAFÍN Peptidyl-dipeptidase A Sarcoidosis Seizures The nervous system is affected in 10% of patients with sarcoidosis. However, neurological disturbances are rarely the frst manifestation of the disease. We report a 36-year-old woman presenting with partial seizures that generalized secondarily. Magnetic resonance showed a left parietal cortical-subcortical lesion with a minimal mass effect, moderate vasogenic edema and intense enhancement with intravenous contrast. A magnetic resonance spectroscopy disclosed a low aggressiveness profle, compatible with an infammatory lesion. Angiotensin converting enzyme levels were normal. The lesion was excised and the pathological study showed the presence of granulomas with dubious necrosis. The patient was treated with antituberculous drugs. One year later, the lesion had grown and a thorax CT scan showed numerous mediastinal and hilar lymphadenopathies. A new determination of angiotensin converting enzyme disclosed elevated levels and the biopsy of mediastinal lymph nodes confrmed the presence of sarcoidosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.4 20102010-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400012es10.4067/S0034-98872010000400012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Peptidyl-dipeptidase A Sarcoidosis Seizures
spellingShingle	Peptidyl-dipeptidase A Sarcoidosis Seizures FERNÁNDEZ-REY,CRISTINA LIDIA SAIZ AYALA,ANTONIO ÁLVAREZ-URÍA TEJERO,MARÍA JESÚS SANTAMARTA LIÉBANA,ELENA COSTILLA GARCÍA,SERAFÍN Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
description	The nervous system is affected in 10% of patients with sarcoidosis. However, neurological disturbances are rarely the frst manifestation of the disease. We report a 36-year-old woman presenting with partial seizures that generalized secondarily. Magnetic resonance showed a left parietal cortical-subcortical lesion with a minimal mass effect, moderate vasogenic edema and intense enhancement with intravenous contrast. A magnetic resonance spectroscopy disclosed a low aggressiveness profle, compatible with an infammatory lesion. Angiotensin converting enzyme levels were normal. The lesion was excised and the pathological study showed the presence of granulomas with dubious necrosis. The patient was treated with antituberculous drugs. One year later, the lesion had grown and a thorax CT scan showed numerous mediastinal and hilar lymphadenopathies. A new determination of angiotensin converting enzyme disclosed elevated levels and the biopsy of mediastinal lymph nodes confrmed the presence of sarcoidosis.
author	FERNÁNDEZ-REY,CRISTINA LIDIA SAIZ AYALA,ANTONIO ÁLVAREZ-URÍA TEJERO,MARÍA JESÚS SANTAMARTA LIÉBANA,ELENA COSTILLA GARCÍA,SERAFÍN
author_facet	FERNÁNDEZ-REY,CRISTINA LIDIA SAIZ AYALA,ANTONIO ÁLVAREZ-URÍA TEJERO,MARÍA JESÚS SANTAMARTA LIÉBANA,ELENA COSTILLA GARCÍA,SERAFÍN
author_sort	FERNÁNDEZ-REY,CRISTINA LIDIA
title	Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
title_short	Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
title_full	Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
title_fullStr	Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
title_full_unstemmed	Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico
title_sort	crisis epiléptica como primera manifestación de sarcoidosis: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400012
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Crisis epiléptica como primera manifestación de sarcoidosis: Caso clínico

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