Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?

Due to their effcacy and convenience, low-molecular-weight heparins (LMWH) are used as sustitutes of unfractionated heparin. Unfortunately, most of the evidence about safety and usefulness of LMWH have excluded patients with chronic kidney disease (CKD), in whom their elimination clearance is reduce...

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Autores principales:	VEGA S,JORGE, MARTÍNEZ R,GONZALO, GOECKE S,HELMUTH
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Heparin, low-molecular weight Kidney diseases Kidney failure, chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400015
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spelling	oai:scielo:S0034-988720100004000152010-06-30Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?VEGA S,JORGEMARTÍNEZ R,GONZALOGOECKE S,HELMUTH Heparin, low-molecular weight Kidney diseases Kidney failure, chronic Due to their effcacy and convenience, low-molecular-weight heparins (LMWH) are used as sustitutes of unfractionated heparin. Unfortunately, most of the evidence about safety and usefulness of LMWH have excluded patients with chronic kidney disease (CKD), in whom their elimination clearance is reduced, allowing an increased anticoagulant effect. Accordingly, there is a growing number of reports about major and fatal bleeding episodes in this group of patients using LMWH. At the present stage of knowledge, there is no defnitive cut-off value of renal function to adjust the doses or avoid the administration of LMWH, making their effects unpredictable in patients with CKD. Hence, it is reasonable to avoid the use of these drugs in patients with CKD, while awaiting for more evidence that supports their safer use.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.4 20102010-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400015es10.4067/S0034-98872010000400015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Heparin, low-molecular weight Kidney diseases Kidney failure, chronic
spellingShingle	Heparin, low-molecular weight Kidney diseases Kidney failure, chronic VEGA S,JORGE MARTÍNEZ R,GONZALO GOECKE S,HELMUTH Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
description	Due to their effcacy and convenience, low-molecular-weight heparins (LMWH) are used as sustitutes of unfractionated heparin. Unfortunately, most of the evidence about safety and usefulness of LMWH have excluded patients with chronic kidney disease (CKD), in whom their elimination clearance is reduced, allowing an increased anticoagulant effect. Accordingly, there is a growing number of reports about major and fatal bleeding episodes in this group of patients using LMWH. At the present stage of knowledge, there is no defnitive cut-off value of renal function to adjust the doses or avoid the administration of LMWH, making their effects unpredictable in patients with CKD. Hence, it is reasonable to avoid the use of these drugs in patients with CKD, while awaiting for more evidence that supports their safer use.
author	VEGA S,JORGE MARTÍNEZ R,GONZALO GOECKE S,HELMUTH
author_facet	VEGA S,JORGE MARTÍNEZ R,GONZALO GOECKE S,HELMUTH
author_sort	VEGA S,JORGE
title	Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
title_short	Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
title_full	Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
title_fullStr	Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
title_full_unstemmed	Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?
title_sort	heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿es seguro su uso?
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000400015
work_keys_str_mv	AT vegasjorge heparinasdebajopesomolecularenpacientesconenfermedadrenalcronicaessegurosuuso AT martinezrgonzalo heparinasdebajopesomolecularenpacientesconenfermedadrenalcronicaessegurosuuso AT goeckeshelmuth heparinasdebajopesomolecularenpacientesconenfermedadrenalcronicaessegurosuuso
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Heparinas de bajo peso molecular en pacientes con enfermedad renal crónica ¿Es seguro su uso?

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