Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes

Infection with Helicobacter pylori (H. pylori) is highly prevalent in Chile, but there are no systematic studies in patients with upper gastrointestinal symptoms. Aim: To determine the prevalence of H. pylori infection, according to age, gender and endoscopic pathology in a large sample of patients....

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Autores principales:	ORTEGA,JUAN PABLO, ESPINO,ALBERTO, CALVO B,ALFONSO, VERDUGO,PATRICIA, PRUYAS,MARTHA, NILSEN,EVA, VILLARROEL,LUIS, PADILLA,OSLANDO, RIQUELME,ARNOLDO, ROLLÁN,ANTONIO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Helicobacter pylori Epidemiology Peptic ulcer Gastroscopy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500001
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spelling	oai:scielo:S0034-988720100005000012010-07-12Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientesORTEGA,JUAN PABLOESPINO,ALBERTOCALVO B,ALFONSOVERDUGO,PATRICIAPRUYAS,MARTHANILSEN,EVAVILLARROEL,LUISPADILLA,OSLANDORIQUELME,ARNOLDOROLLÁN,ANTONIO Helicobacter pylori Epidemiology Peptic ulcer Gastroscopy Infection with Helicobacter pylori (H. pylori) is highly prevalent in Chile, but there are no systematic studies in patients with upper gastrointestinal symptoms. Aim: To determine the prevalence of H. pylori infection, according to age, gender and endoscopic pathology in a large sample of patients. Methods: We studied 7,893 symptomatic patients submitted to upper gastrointestinal endoscopy between July 1996 and December 2003 in the context of a screening program of gastric cancer in a high risk population. H. pylori infection was determined by rapid urease test (RUT) in antral mucosa. We excluded 158 patients with gastric cancer (2%) and 2,071 patients without RUT. Results: We included 5,664 patients, mean age 50.7 ± 13.9 years, women 72.1%. Endoscopic diagnoses were normal in 59.3%, erosive esophagitis in 20%, gastric ulcer (GU) in 8.1%, duodenal ulcer (DU) in 6.4%, and erosive gastropathy in 6.2%. RUT was positive in 78% of patients. After adjusting for age and sex and with respect to patients with normal endoscopy, frequency of H. pylori infection was 86.6% in DU (OR 2.1, 95% CI 1.5-2.8, p < 0.001); 81.4% in GU (OR 1.8, 95% CI 1.4-2.4; p < 0.001 ); 79.9% in erosive gastropathy (OR 1.4, 95% CI 1.03-1.8; p = 0.03) and 77.4% in erosive esophagitis (OR 1.1, 95% CI: 0.9-1.3; p = NS). The probability of H. pylori infection decreased significantly with age, more markedly in men with normal endoscopy. Conclusions: Prevalence of H. pylori infection is very high in symptomatic Chilean patients and even higher in those with gastroduodenal ulcer or erosions, while in patients with erosive esophagitis is similar to those with normal endoscopy. The frequency of infection decreases with age, probably as a consequence of rising frequency of gastric mucosal atrophy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.5 20102010-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500001es10.4067/S0034-98872010000500001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Helicobacter pylori Epidemiology Peptic ulcer Gastroscopy
spellingShingle	Helicobacter pylori Epidemiology Peptic ulcer Gastroscopy ORTEGA,JUAN PABLO ESPINO,ALBERTO CALVO B,ALFONSO VERDUGO,PATRICIA PRUYAS,MARTHA NILSEN,EVA VILLARROEL,LUIS PADILLA,OSLANDO RIQUELME,ARNOLDO ROLLÁN,ANTONIO Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
description	Infection with Helicobacter pylori (H. pylori) is highly prevalent in Chile, but there are no systematic studies in patients with upper gastrointestinal symptoms. Aim: To determine the prevalence of H. pylori infection, according to age, gender and endoscopic pathology in a large sample of patients. Methods: We studied 7,893 symptomatic patients submitted to upper gastrointestinal endoscopy between July 1996 and December 2003 in the context of a screening program of gastric cancer in a high risk population. H. pylori infection was determined by rapid urease test (RUT) in antral mucosa. We excluded 158 patients with gastric cancer (2%) and 2,071 patients without RUT. Results: We included 5,664 patients, mean age 50.7 ± 13.9 years, women 72.1%. Endoscopic diagnoses were normal in 59.3%, erosive esophagitis in 20%, gastric ulcer (GU) in 8.1%, duodenal ulcer (DU) in 6.4%, and erosive gastropathy in 6.2%. RUT was positive in 78% of patients. After adjusting for age and sex and with respect to patients with normal endoscopy, frequency of H. pylori infection was 86.6% in DU (OR 2.1, 95% CI 1.5-2.8, p < 0.001); 81.4% in GU (OR 1.8, 95% CI 1.4-2.4; p < 0.001 ); 79.9% in erosive gastropathy (OR 1.4, 95% CI 1.03-1.8; p = 0.03) and 77.4% in erosive esophagitis (OR 1.1, 95% CI: 0.9-1.3; p = NS). The probability of H. pylori infection decreased significantly with age, more markedly in men with normal endoscopy. Conclusions: Prevalence of H. pylori infection is very high in symptomatic Chilean patients and even higher in those with gastroduodenal ulcer or erosions, while in patients with erosive esophagitis is similar to those with normal endoscopy. The frequency of infection decreases with age, probably as a consequence of rising frequency of gastric mucosal atrophy.
author	ORTEGA,JUAN PABLO ESPINO,ALBERTO CALVO B,ALFONSO VERDUGO,PATRICIA PRUYAS,MARTHA NILSEN,EVA VILLARROEL,LUIS PADILLA,OSLANDO RIQUELME,ARNOLDO ROLLÁN,ANTONIO
author_facet	ORTEGA,JUAN PABLO ESPINO,ALBERTO CALVO B,ALFONSO VERDUGO,PATRICIA PRUYAS,MARTHA NILSEN,EVA VILLARROEL,LUIS PADILLA,OSLANDO RIQUELME,ARNOLDO ROLLÁN,ANTONIO
author_sort	ORTEGA,JUAN PABLO
title	Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
title_short	Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
title_full	Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
title_fullStr	Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
title_full_unstemmed	Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes
title_sort	infección por helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: análisis de 5.664 pacientes
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500001
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Infección por Helicobacter pylori en pacientes sintomáticos con patología gastroduodenal benigna: Análisis de 5.664 pacientes

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