Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar

This article aims to review the most relevant morphological and molecular aspects involved in gallbladder (GB) cancer. In Chile, gallbladder cancer is the main cause of death due to cancer, among women older than 40 years. However, there is almost none information about the morphological changes and...

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Autores principales:	CASTILLO A,JONATHAN, GARCÍA M,PATRICIA, ROA S,JUAN CARLOS
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Epigenesis, genetics Gallbladder neoplasms Molecular biology
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500011
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spelling	oai:scielo:S0034-988720100005000112010-07-12Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliarCASTILLO A,JONATHANGARCÍA M,PATRICIAROA S,JUAN CARLOS Epigenesis, genetics Gallbladder neoplasms Molecular biology This article aims to review the most relevant morphological and molecular aspects involved in gallbladder (GB) cancer. In Chile, gallbladder cancer is the main cause of death due to cancer, among women older than 40 years. However, there is almost none information about the morphological changes and the genetic alterations in-volved in the beginning and development of this neoplasia. Two carcinogenic ways have been described. The sequence adenoma-carcinoma is accepted to be less frequent and important. The most important is the sequence where a metaplasia evolves to displasia that progresses to carcinoma in situ and fnally it becomes invasive. This progress requires 10 to 15 years approximately. During this time, a continue progression of injuries have been described. Molecular research studies show genetic anomalies in some genes which are temporary events in preneoplastic injuries of the gallbladder. Some of them even exist before the frst morphological changes, while the expression of tumor suppressor genes like p53, adhesion molecules and oncogenes, among others, can be related to late GB carcinogenesis. The K-ras gene seems to play a role in this neoplasia, mainly in those that present an abnormal biliopancreatic union. The microsatelital instability has been found in a small subset of preneoplastic and neoplastic lesions. The existence of methylation in the promotor gene areas has been related to the cellular proliferation, invasion and metastasis and also in cases of chronic cholecystitis, suggesting that this epigenetic phenomenon represents a crucial early event in GB carcinogenesis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.5 20102010-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500011es10.4067/S0034-98872010000500011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Epigenesis, genetics Gallbladder neoplasms Molecular biology
spellingShingle	Epigenesis, genetics Gallbladder neoplasms Molecular biology CASTILLO A,JONATHAN GARCÍA M,PATRICIA ROA S,JUAN CARLOS Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
description	This article aims to review the most relevant morphological and molecular aspects involved in gallbladder (GB) cancer. In Chile, gallbladder cancer is the main cause of death due to cancer, among women older than 40 years. However, there is almost none information about the morphological changes and the genetic alterations in-volved in the beginning and development of this neoplasia. Two carcinogenic ways have been described. The sequence adenoma-carcinoma is accepted to be less frequent and important. The most important is the sequence where a metaplasia evolves to displasia that progresses to carcinoma in situ and fnally it becomes invasive. This progress requires 10 to 15 years approximately. During this time, a continue progression of injuries have been described. Molecular research studies show genetic anomalies in some genes which are temporary events in preneoplastic injuries of the gallbladder. Some of them even exist before the frst morphological changes, while the expression of tumor suppressor genes like p53, adhesion molecules and oncogenes, among others, can be related to late GB carcinogenesis. The K-ras gene seems to play a role in this neoplasia, mainly in those that present an abnormal biliopancreatic union. The microsatelital instability has been found in a small subset of preneoplastic and neoplastic lesions. The existence of methylation in the promotor gene areas has been related to the cellular proliferation, invasion and metastasis and also in cases of chronic cholecystitis, suggesting that this epigenetic phenomenon represents a crucial early event in GB carcinogenesis.
author	CASTILLO A,JONATHAN GARCÍA M,PATRICIA ROA S,JUAN CARLOS
author_facet	CASTILLO A,JONATHAN GARCÍA M,PATRICIA ROA S,JUAN CARLOS
author_sort	CASTILLO A,JONATHAN
title	Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
title_short	Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
title_full	Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
title_fullStr	Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
title_full_unstemmed	Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
title_sort	alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500011
work_keys_str_mv	AT castilloajonathan alteracionesgeneticasenlesionespreneoplasicasyneoplasicasdelavesiculabiliar AT garciampatricia alteracionesgeneticasenlesionespreneoplasicasyneoplasicasdelavesiculabiliar AT roasjuancarlos alteracionesgeneticasenlesionespreneoplasicasyneoplasicasdelavesiculabiliar
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Alteraciones genéticas en lesiones preneoplásicas y neoplásicas de la vesícula biliar

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