Participación del sistema endocanabinoide en el desarrollo de obesidad

Endocannabinoids are the endogenous ligands for the cannabinoid receptors type 1 and 2. These membrane receptors are responsible for the psychotropic effects of Cannabis Sativa, when bound to its active component known as (-)-Δ9-tetrahydro-cannabinol. Cannabinoid receptors, endocannabinoids...

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Autores principales:	VALENZUELA,CARINA, AGUIRRE,CAROLINA, CASTILLO,VALESKA, RONCO,ANA MARÍA, LLANOS,MIGUEL
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	CB1 Receptor Endocannabinoids Lipogenesis Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500014
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record_format	dspace
spelling	oai:scielo:S0034-988720100005000142010-07-12Participación del sistema endocanabinoide en el desarrollo de obesidadVALENZUELA,CARINAAGUIRRE,CAROLINACASTILLO,VALESKARONCO,ANA MARÍALLANOS,MIGUEL CB1 Receptor Endocannabinoids Lipogenesis Obesity Endocannabinoids are the endogenous ligands for the cannabinoid receptors type 1 and 2. These membrane receptors are responsible for the psychotropic effects of Cannabis Sativa, when bound to its active component known as (-)-Δ9-tetrahydro-cannabinol. Cannabinoid receptors, endocannabinoids and the enzymes catalyzing their biosynthesis and degradation, constitute the endocannabinoid system (ECS), which has a remarkable role controlling energy balance, both at central nervous system and peripheral tissues. The ECS regulates food ingestion by stimulating a network of orexigenic neurons present in the hypothalamus and reinforcing motivation and reward to food consumption in the nucleus accumbens. Regarding peripheral tissues, this system controls lipid and glucose metabolism at different levels, reduces energy expenditure and leads energy balance to fat storage. Metabolic alterations, includ-ing excessive accumulation of abdominal fat, dyslipidaemia and hyperglicaemia, are suggested to be associated to a hyperactivated ECS. Since obesity is one of the major health problems in modern societies, in this review we discuss the role of the endocannabinoid system in metabolic pathways associated to control mechanisms of energy balance and its involvement in overweight and obesity. In addition, we also discuss therapeutic possibilities and emergent problems due to cannabinoid receptor type 1 antagonism utilized as treatment for such alterations.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.5 20102010-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500014es10.4067/S0034-98872010000500014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	CB1 Receptor Endocannabinoids Lipogenesis Obesity
spellingShingle	CB1 Receptor Endocannabinoids Lipogenesis Obesity VALENZUELA,CARINA AGUIRRE,CAROLINA CASTILLO,VALESKA RONCO,ANA MARÍA LLANOS,MIGUEL Participación del sistema endocanabinoide en el desarrollo de obesidad
description	Endocannabinoids are the endogenous ligands for the cannabinoid receptors type 1 and 2. These membrane receptors are responsible for the psychotropic effects of Cannabis Sativa, when bound to its active component known as (-)-Δ9-tetrahydro-cannabinol. Cannabinoid receptors, endocannabinoids and the enzymes catalyzing their biosynthesis and degradation, constitute the endocannabinoid system (ECS), which has a remarkable role controlling energy balance, both at central nervous system and peripheral tissues. The ECS regulates food ingestion by stimulating a network of orexigenic neurons present in the hypothalamus and reinforcing motivation and reward to food consumption in the nucleus accumbens. Regarding peripheral tissues, this system controls lipid and glucose metabolism at different levels, reduces energy expenditure and leads energy balance to fat storage. Metabolic alterations, includ-ing excessive accumulation of abdominal fat, dyslipidaemia and hyperglicaemia, are suggested to be associated to a hyperactivated ECS. Since obesity is one of the major health problems in modern societies, in this review we discuss the role of the endocannabinoid system in metabolic pathways associated to control mechanisms of energy balance and its involvement in overweight and obesity. In addition, we also discuss therapeutic possibilities and emergent problems due to cannabinoid receptor type 1 antagonism utilized as treatment for such alterations.
author	VALENZUELA,CARINA AGUIRRE,CAROLINA CASTILLO,VALESKA RONCO,ANA MARÍA LLANOS,MIGUEL
author_facet	VALENZUELA,CARINA AGUIRRE,CAROLINA CASTILLO,VALESKA RONCO,ANA MARÍA LLANOS,MIGUEL
author_sort	VALENZUELA,CARINA
title	Participación del sistema endocanabinoide en el desarrollo de obesidad
title_short	Participación del sistema endocanabinoide en el desarrollo de obesidad
title_full	Participación del sistema endocanabinoide en el desarrollo de obesidad
title_fullStr	Participación del sistema endocanabinoide en el desarrollo de obesidad
title_full_unstemmed	Participación del sistema endocanabinoide en el desarrollo de obesidad
title_sort	participación del sistema endocanabinoide en el desarrollo de obesidad
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000500014
work_keys_str_mv	AT valenzuelacarina participaciondelsistemaendocanabinoideeneldesarrollodeobesidad AT aguirrecarolina participaciondelsistemaendocanabinoideeneldesarrollodeobesidad AT castillovaleska participaciondelsistemaendocanabinoideeneldesarrollodeobesidad AT roncoanamaria participaciondelsistemaendocanabinoideeneldesarrollodeobesidad AT llanosmiguel participaciondelsistemaendocanabinoideeneldesarrollodeobesidad
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Participación del sistema endocanabinoide en el desarrollo de obesidad

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