Marcadores genéticos en hipertensión esencial

Essential hypertension (HTA) is a multifactorial disease and in Chile, its prevalence is 33.7%. There is a genetic predisposition to develop hypertension, whose magnitude is approximately 30 to 50%. At present, some factors are known to increase the risk for cardiovascular disease, but widely accept...

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Autores principales:	PASSALACQUA,CRISTÓBAL, CASTILLO TAUCHER,SILVIA
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Gene components Heredity Hypertension
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000600016
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spelling	oai:scielo:S0034-988720100006000162010-08-31Marcadores genéticos en hipertensión esencialPASSALACQUA,CRISTÓBALCASTILLO TAUCHER,SILVIA Gene components Heredity Hypertension Essential hypertension (HTA) is a multifactorial disease and in Chile, its prevalence is 33.7%. There is a genetic predisposition to develop hypertension, whose magnitude is approximately 30 to 50%. At present, some factors are known to increase the risk for cardiovascular disease, but widely accepted biomarkers for screening are missing. The frst studies that looked for candidate genes have focused on the reninangiotensin - aldosterone, aducina, adrenoreceptors ß, G protein subunits, G protein signaling regulators, kinases associated with G proteins and Rho kinases. Studies of DNA sequencing, search for polymorphisms and variants through single nucleotide polymorphisms, have been used to seek partnerships with complex or multifactorial diseases, like HTA. Examples of these are: components of collagen proteins, genes related to cell myocardial proteins belonging to cytochrome P450 and growth factors, among others. It is still unlikely to count in a near future with a universal marker. Most probably, a series of markers that confer susceptibility to a specifc individual will have to be used in prevention programs or personalized therapy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.6 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000600016es10.4067/S0034-98872010000600016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Gene components Heredity Hypertension
spellingShingle	Gene components Heredity Hypertension PASSALACQUA,CRISTÓBAL CASTILLO TAUCHER,SILVIA Marcadores genéticos en hipertensión esencial
description	Essential hypertension (HTA) is a multifactorial disease and in Chile, its prevalence is 33.7%. There is a genetic predisposition to develop hypertension, whose magnitude is approximately 30 to 50%. At present, some factors are known to increase the risk for cardiovascular disease, but widely accepted biomarkers for screening are missing. The frst studies that looked for candidate genes have focused on the reninangiotensin - aldosterone, aducina, adrenoreceptors ß, G protein subunits, G protein signaling regulators, kinases associated with G proteins and Rho kinases. Studies of DNA sequencing, search for polymorphisms and variants through single nucleotide polymorphisms, have been used to seek partnerships with complex or multifactorial diseases, like HTA. Examples of these are: components of collagen proteins, genes related to cell myocardial proteins belonging to cytochrome P450 and growth factors, among others. It is still unlikely to count in a near future with a universal marker. Most probably, a series of markers that confer susceptibility to a specifc individual will have to be used in prevention programs or personalized therapy.
author	PASSALACQUA,CRISTÓBAL CASTILLO TAUCHER,SILVIA
author_facet	PASSALACQUA,CRISTÓBAL CASTILLO TAUCHER,SILVIA
author_sort	PASSALACQUA,CRISTÓBAL
title	Marcadores genéticos en hipertensión esencial
title_short	Marcadores genéticos en hipertensión esencial
title_full	Marcadores genéticos en hipertensión esencial
title_fullStr	Marcadores genéticos en hipertensión esencial
title_full_unstemmed	Marcadores genéticos en hipertensión esencial
title_sort	marcadores genéticos en hipertensión esencial
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000600016
work_keys_str_mv	AT passalacquacristobal marcadoresgeneticosenhipertensionesencial AT castillotauchersilvia marcadoresgeneticosenhipertensionesencial
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