Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales

Triglyceride concentrations are an independent risk factor for coronary heart disease. Apolipoprotein A5 gene (APOA5) has an important role determining triglyceride metabolism and it is a potential cardiovascular risk. However the mechanisms for these actions are not well-known. Despite the differen...

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Autores principales:	SOTOS-PRIETO,MERCEDES, FRANCÉS,FRANCESC, CORELLA,DOLORES
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	APOA5 protein human Coronary disease Triglycerides
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700013
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spelling	oai:scielo:S0034-988720100007000132010-11-26Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientalesSOTOS-PRIETO,MERCEDESFRANCÉS,FRANCESCCORELLA,DOLORES APOA5 protein human Coronary disease Triglycerides Triglyceride concentrations are an independent risk factor for coronary heart disease. Apolipoprotein A5 gene (APOA5) has an important role determining triglyceride metabolism and it is a potential cardiovascular risk. However the mechanisms for these actions are not well-known. Despite the different allelic frequency of its major polymorphisms in different populations, multiple studies have shown consistent associations between these variants and fasting triglycerides. Variations in the APOA5 gene have also been associated with postprandial triglycerides, as well as with different sizes of lipoproteins and other markers. Moreover, some of the APOA5 gene variants have been associated with ischemic heart disease, stroke, and carotid intima media thickness, although the references on this issue are scanty and contradictory. This may be due to the presence of gene-environment interactions that have been poorly studied until now. Among the few studies that have examined the infuence of environmental factors on possible genetic variations, the most important are those that contemplate possible gene-diet interactions. However, the evidence is still scarce and more research is required in the feld of nutrigenomics. To understand the impact of this gene on cardiovascular disease, we review the genetic functionality and variability of APOA5, its associations with intermediate and fnal phenotypes and gene-environment interactions detected.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.7 20102010-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700013es10.4067/S0034-98872010000700013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	APOA5 protein human Coronary disease Triglycerides
spellingShingle	APOA5 protein human Coronary disease Triglycerides SOTOS-PRIETO,MERCEDES FRANCÉS,FRANCESC CORELLA,DOLORES Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
description	Triglyceride concentrations are an independent risk factor for coronary heart disease. Apolipoprotein A5 gene (APOA5) has an important role determining triglyceride metabolism and it is a potential cardiovascular risk. However the mechanisms for these actions are not well-known. Despite the different allelic frequency of its major polymorphisms in different populations, multiple studies have shown consistent associations between these variants and fasting triglycerides. Variations in the APOA5 gene have also been associated with postprandial triglycerides, as well as with different sizes of lipoproteins and other markers. Moreover, some of the APOA5 gene variants have been associated with ischemic heart disease, stroke, and carotid intima media thickness, although the references on this issue are scanty and contradictory. This may be due to the presence of gene-environment interactions that have been poorly studied until now. Among the few studies that have examined the infuence of environmental factors on possible genetic variations, the most important are those that contemplate possible gene-diet interactions. However, the evidence is still scarce and more research is required in the feld of nutrigenomics. To understand the impact of this gene on cardiovascular disease, we review the genetic functionality and variability of APOA5, its associations with intermediate and fnal phenotypes and gene-environment interactions detected.
author	SOTOS-PRIETO,MERCEDES FRANCÉS,FRANCESC CORELLA,DOLORES
author_facet	SOTOS-PRIETO,MERCEDES FRANCÉS,FRANCESC CORELLA,DOLORES
author_sort	SOTOS-PRIETO,MERCEDES
title	Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
title_short	Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
title_full	Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
title_fullStr	Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
title_full_unstemmed	Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales
title_sort	impacto de la apolipoproteína a5 en el riesgo cardiovascular: modulaciones genéticas y ambientales
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700013
work_keys_str_mv	AT sotosprietomercedes impactodelaapolipoproteinaa5enelriesgocardiovascularmodulacionesgeneticasyambientales AT francesfrancesc impactodelaapolipoproteinaa5enelriesgocardiovascularmodulacionesgeneticasyambientales AT corelladolores impactodelaapolipoproteinaa5enelriesgocardiovascularmodulacionesgeneticasyambientales
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Impacto de la apolipoproteína A5 en el riesgo cardiovascular: Modulaciones genéticas y ambientales

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