Terapias biológicas en el lupus eritematoso sistémico

The immunosuppressive agents used in patients with systemic lupus erythematosus (SLE) have signifcantly improved prognosis. However, it is necessary to develop more specifc immunosuppressive treatments with less toxicity. Better understanding of the mechanisms involved in the loss of tolerance in au...

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Autores principales:	CAIROLI,ERNESTO, ESPINOSA,GERARD, CERVERA,RICARD
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Antibodies, monoclonal B cell activating factor Biological therapy Lupus erythematosus, systemic Rituximab
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700014
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spelling	oai:scielo:S0034-988720100007000142010-11-26Terapias biológicas en el lupus eritematoso sistémicoCAIROLI,ERNESTOESPINOSA,GERARDCERVERA,RICARD Antibodies, monoclonal B cell activating factor Biological therapy Lupus erythematosus, systemic Rituximab The immunosuppressive agents used in patients with systemic lupus erythematosus (SLE) have signifcantly improved prognosis. However, it is necessary to develop more specifc immunosuppressive treatments with less toxicity. Better understanding of the mechanisms involved in the loss of tolerance in autoimmune diseases has contributed to the development of potential new treatments called biologic therapies. The targets of these biological therapies are directed toward the B cell depletion, interference in the co-stimulation signals and the blockade of cytokines. Therapies using anti-CD20 monoclonal antibodies have shown satisfactory results especially in patients with SLE refractory to conventional treatment. The biological therapies provide encouraging results that represent a possible option in the treatment of refractory patients as well as a potential therapy in the future management of SLE.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.7 20102010-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700014es10.4067/S0034-98872010000700014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibodies, monoclonal B cell activating factor Biological therapy Lupus erythematosus, systemic Rituximab
spellingShingle	Antibodies, monoclonal B cell activating factor Biological therapy Lupus erythematosus, systemic Rituximab CAIROLI,ERNESTO ESPINOSA,GERARD CERVERA,RICARD Terapias biológicas en el lupus eritematoso sistémico
description	The immunosuppressive agents used in patients with systemic lupus erythematosus (SLE) have signifcantly improved prognosis. However, it is necessary to develop more specifc immunosuppressive treatments with less toxicity. Better understanding of the mechanisms involved in the loss of tolerance in autoimmune diseases has contributed to the development of potential new treatments called biologic therapies. The targets of these biological therapies are directed toward the B cell depletion, interference in the co-stimulation signals and the blockade of cytokines. Therapies using anti-CD20 monoclonal antibodies have shown satisfactory results especially in patients with SLE refractory to conventional treatment. The biological therapies provide encouraging results that represent a possible option in the treatment of refractory patients as well as a potential therapy in the future management of SLE.
author	CAIROLI,ERNESTO ESPINOSA,GERARD CERVERA,RICARD
author_facet	CAIROLI,ERNESTO ESPINOSA,GERARD CERVERA,RICARD
author_sort	CAIROLI,ERNESTO
title	Terapias biológicas en el lupus eritematoso sistémico
title_short	Terapias biológicas en el lupus eritematoso sistémico
title_full	Terapias biológicas en el lupus eritematoso sistémico
title_fullStr	Terapias biológicas en el lupus eritematoso sistémico
title_full_unstemmed	Terapias biológicas en el lupus eritematoso sistémico
title_sort	terapias biológicas en el lupus eritematoso sistémico
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700014
work_keys_str_mv	AT cairoliernesto terapiasbiologicasenellupuseritematososistemico AT espinosagerard terapiasbiologicasenellupuseritematososistemico AT cerveraricard terapiasbiologicasenellupuseritematososistemico
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Terapias biológicas en el lupus eritematoso sistémico

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