Disfunción miocárdica en la sepsis

Myocardial dysfunction appears in 25% of patients with severe sepsis and in 50% of patients with septic shock, even in the presence of hyper dynamic states. It is characterized by a reduction in left ventricle ejection fraction, that reverts at the seventh to tenth day of evolution. Right ventricula...

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Autores principales:	ANDRESEN,MAX, REGUEIRA,TOMÁS
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Cardiomyopathies Heart failure Sepsis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700015
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spelling	oai:scielo:S0034-988720100007000152010-11-26Disfunción miocárdica en la sepsisANDRESEN,MAXREGUEIRA,TOMÁS Cardiomyopathies Heart failure Sepsis Myocardial dysfunction appears in 25% of patients with severe sepsis and in 50% of patients with septic shock, even in the presence of hyper dynamic states. It is characterized by a reduction in left ventricle ejection fraction, that reverts at the seventh to tenth day of evolution. Right ventricular dysfunction and diastolic left ventricular dysfunction can also appear. There is no consensus if an increase in end diastolic volume is part of the syndrome. High troponin or brain natriuretic peptide levels are associated with myocardial dysfunction and a higher mortality. The pathogenesis of myocardial dysfunction is related to micro and macro circulatory changes, infammatory response, oxidative stress, intracellular calcium management disturbances, metabolic changes, autonomic dysfunction, activation of apoptosis, mitochondrial abnormalities and a derangement in catecholaminergic stimulation. Since there is no specifc treatment for myocardial dysfunction, its management requires an adequate multi systemic support to maintain perfusion pressures and systemic fows suffcient for the regional and global demands.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.7 20102010-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700015es10.4067/S0034-98872010000700015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cardiomyopathies Heart failure Sepsis
spellingShingle	Cardiomyopathies Heart failure Sepsis ANDRESEN,MAX REGUEIRA,TOMÁS Disfunción miocárdica en la sepsis
description	Myocardial dysfunction appears in 25% of patients with severe sepsis and in 50% of patients with septic shock, even in the presence of hyper dynamic states. It is characterized by a reduction in left ventricle ejection fraction, that reverts at the seventh to tenth day of evolution. Right ventricular dysfunction and diastolic left ventricular dysfunction can also appear. There is no consensus if an increase in end diastolic volume is part of the syndrome. High troponin or brain natriuretic peptide levels are associated with myocardial dysfunction and a higher mortality. The pathogenesis of myocardial dysfunction is related to micro and macro circulatory changes, infammatory response, oxidative stress, intracellular calcium management disturbances, metabolic changes, autonomic dysfunction, activation of apoptosis, mitochondrial abnormalities and a derangement in catecholaminergic stimulation. Since there is no specifc treatment for myocardial dysfunction, its management requires an adequate multi systemic support to maintain perfusion pressures and systemic fows suffcient for the regional and global demands.
author	ANDRESEN,MAX REGUEIRA,TOMÁS
author_facet	ANDRESEN,MAX REGUEIRA,TOMÁS
author_sort	ANDRESEN,MAX
title	Disfunción miocárdica en la sepsis
title_short	Disfunción miocárdica en la sepsis
title_full	Disfunción miocárdica en la sepsis
title_fullStr	Disfunción miocárdica en la sepsis
title_full_unstemmed	Disfunción miocárdica en la sepsis
title_sort	disfunción miocárdica en la sepsis
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010000700015
work_keys_str_mv	AT andresenmax disfuncionmiocardicaenlasepsis AT regueiratomas disfuncionmiocardicaenlasepsis
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Disfunción miocárdica en la sepsis

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