El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía

Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-α and IL-6 among pati...

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Autores principales:	MIRANDA-DÍAZ,ALEJANDRA G, HERMOSILLO-SANDOVAL,JOSÉ M, HUERTA-ROSAS,GONZALO, LÓPEZ-GUILLÉN,GERMÁN G, CARDONA MUÑOZ,ERNESTO G, GARCÍA-IGLESIAS,TRINIDAD, PACHECO-MOISÉS,FERMÍN, ALATORRE-CARRANZA,MARÍA DEL P
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Bile ducts extrahepatic Interleukin-6 Tumor necrosis factor-alpha
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100008
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spelling	oai:scielo:S0034-988720100011000082011-01-10El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomíaMIRANDA-DÍAZ,ALEJANDRA GHERMOSILLO-SANDOVAL,JOSÉ MHUERTA-ROSAS,GONZALOLÓPEZ-GUILLÉN,GERMÁN GCARDONA MUÑOZ,ERNESTO GGARCÍA-IGLESIAS,TRINIDADPACHECO-MOISÉS,FERMÍNALATORRE-CARRANZA,MARÍA DEL P Bile ducts extrahepatic Interleukin-6 Tumor necrosis factor-alpha Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-α and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and Methods: Serum levels of TNF-α and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. Results: At baseline TNF-α levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-á became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients. Conclusions: TNF-α and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.10 20102010-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100008es10.4067/S0034-98872010001100008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bile ducts extrahepatic Interleukin-6 Tumor necrosis factor-alpha
spellingShingle	Bile ducts extrahepatic Interleukin-6 Tumor necrosis factor-alpha MIRANDA-DÍAZ,ALEJANDRA G HERMOSILLO-SANDOVAL,JOSÉ M HUERTA-ROSAS,GONZALO LÓPEZ-GUILLÉN,GERMÁN G CARDONA MUÑOZ,ERNESTO G GARCÍA-IGLESIAS,TRINIDAD PACHECO-MOISÉS,FERMÍN ALATORRE-CARRANZA,MARÍA DEL P El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
description	Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-α and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and Methods: Serum levels of TNF-α and IL-6 were measured prior to the bile-enteric derivation and after one year of follow up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. Results: At baseline TNF-α levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-á became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients. Conclusions: TNF-α and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later.
author	MIRANDA-DÍAZ,ALEJANDRA G HERMOSILLO-SANDOVAL,JOSÉ M HUERTA-ROSAS,GONZALO LÓPEZ-GUILLÉN,GERMÁN G CARDONA MUÑOZ,ERNESTO G GARCÍA-IGLESIAS,TRINIDAD PACHECO-MOISÉS,FERMÍN ALATORRE-CARRANZA,MARÍA DEL P
author_facet	MIRANDA-DÍAZ,ALEJANDRA G HERMOSILLO-SANDOVAL,JOSÉ M HUERTA-ROSAS,GONZALO LÓPEZ-GUILLÉN,GERMÁN G CARDONA MUÑOZ,ERNESTO G GARCÍA-IGLESIAS,TRINIDAD PACHECO-MOISÉS,FERMÍN ALATORRE-CARRANZA,MARÍA DEL P
author_sort	MIRANDA-DÍAZ,ALEJANDRA G
title	El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
title_short	El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
title_full	El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
title_fullStr	El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
title_full_unstemmed	El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
title_sort	el comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100008
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El comportamiento del factor de necrosis tumoral alfa e interleucina 6 en lesiones de vías biliares postcolecistectomía

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