Hepatitis viruses: Not always what it seems to be

The classic hepatotropic viruses, hepatitis A through E, are not the only viral agents able to infect the liver. Other systemic viruses may cause hepatic injury that can range from mild and transient elevation of aminotransferases to acute hepatitis and occasionally acute liver failure and fulminant...

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Autores principales:	GALLEGOS-OROZCO,JUAN FERNANDO, RAKELA-BRÖDNER,JORGE
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Cytomegalovirus Hepatitis viral human Hepatitis viruses Herpesviridae
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100016
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spelling	oai:scielo:S0034-988720100011000162011-01-10Hepatitis viruses: Not always what it seems to beGALLEGOS-OROZCO,JUAN FERNANDORAKELA-BRÖDNER,JORGE Cytomegalovirus Hepatitis viral human Hepatitis viruses Herpesviridae The classic hepatotropic viruses, hepatitis A through E, are not the only viral agents able to infect the liver. Other systemic viruses may cause hepatic injury that can range from mild and transient elevation of aminotransferases to acute hepatitis and occasionally acute liver failure and fulminant hepatitis. The clinical presentation may be indistinguishable from that associated with classic hepatotropic viruses. These agents include cytomegalovirus; Epstein-Barr virus; herpes simplex virus; varicella-zoster virus; human herpesvirus 6, 7, and 8; human parvovirus B19; adenoviruses among others. Wide spectrums of clinical syndromes are associated with cytomegalovirus disease. Unique clinical syndromes may present in neonates, young adults and immunocompromised hosts infected with cytomegalovirus. Cases of fulminant hepatitis have been reported in both immunocompromised and immunocompetent hosts infected with Epstein Barr virus. Occasionally, these patients with acute hepatic failure may need liver transplantation. Herpes simplex viruses may involve the liver in neonatal infections, pregnancy, immunocompromised hosts and occasionally, immunocompetent adults. Varicella-Zoster virus has also been associated with severe acute hepatitis and fulminant hepatitis in adults. The drug of choice for these conditions is intravenous acyclovir. These may also need liver transplantation in the more severe forms of clinical presentation. Typical liver biopsy findings can be useful in determining the diagnosis of these viral infections. Human herpesviruses 6, 7, and 8, human parvovirus B19, and adenoviruses can also be present with features of acute liver injury and occasionally as fulminant hepatitis. The clinical syndromes are less well delineated than those associated with herpesviruses. It is important to consider these viruses as possible etiologic agents in patients who have acute liver injury and their serologic markers for the classic hepatotropic viruses are not indicative of an active infection.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.10 20102010-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100016en10.4067/S0034-98872010001100016
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Cytomegalovirus Hepatitis viral human Hepatitis viruses Herpesviridae
spellingShingle	Cytomegalovirus Hepatitis viral human Hepatitis viruses Herpesviridae GALLEGOS-OROZCO,JUAN FERNANDO RAKELA-BRÖDNER,JORGE Hepatitis viruses: Not always what it seems to be
description	The classic hepatotropic viruses, hepatitis A through E, are not the only viral agents able to infect the liver. Other systemic viruses may cause hepatic injury that can range from mild and transient elevation of aminotransferases to acute hepatitis and occasionally acute liver failure and fulminant hepatitis. The clinical presentation may be indistinguishable from that associated with classic hepatotropic viruses. These agents include cytomegalovirus; Epstein-Barr virus; herpes simplex virus; varicella-zoster virus; human herpesvirus 6, 7, and 8; human parvovirus B19; adenoviruses among others. Wide spectrums of clinical syndromes are associated with cytomegalovirus disease. Unique clinical syndromes may present in neonates, young adults and immunocompromised hosts infected with cytomegalovirus. Cases of fulminant hepatitis have been reported in both immunocompromised and immunocompetent hosts infected with Epstein Barr virus. Occasionally, these patients with acute hepatic failure may need liver transplantation. Herpes simplex viruses may involve the liver in neonatal infections, pregnancy, immunocompromised hosts and occasionally, immunocompetent adults. Varicella-Zoster virus has also been associated with severe acute hepatitis and fulminant hepatitis in adults. The drug of choice for these conditions is intravenous acyclovir. These may also need liver transplantation in the more severe forms of clinical presentation. Typical liver biopsy findings can be useful in determining the diagnosis of these viral infections. Human herpesviruses 6, 7, and 8, human parvovirus B19, and adenoviruses can also be present with features of acute liver injury and occasionally as fulminant hepatitis. The clinical syndromes are less well delineated than those associated with herpesviruses. It is important to consider these viruses as possible etiologic agents in patients who have acute liver injury and their serologic markers for the classic hepatotropic viruses are not indicative of an active infection.
author	GALLEGOS-OROZCO,JUAN FERNANDO RAKELA-BRÖDNER,JORGE
author_facet	GALLEGOS-OROZCO,JUAN FERNANDO RAKELA-BRÖDNER,JORGE
author_sort	GALLEGOS-OROZCO,JUAN FERNANDO
title	Hepatitis viruses: Not always what it seems to be
title_short	Hepatitis viruses: Not always what it seems to be
title_full	Hepatitis viruses: Not always what it seems to be
title_fullStr	Hepatitis viruses: Not always what it seems to be
title_full_unstemmed	Hepatitis viruses: Not always what it seems to be
title_sort	hepatitis viruses: not always what it seems to be
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001100016
work_keys_str_mv	AT gallegosorozcojuanfernando hepatitisvirusesnotalwayswhatitseemstobe AT rakelabrodnerjorge hepatitisvirusesnotalwayswhatitseemstobe
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Hepatitis viruses: Not always what it seems to be

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