Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino

The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot...

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Autores principales:	LÓPEZ M,JAIME, ILI G,CARMEN GLORIA, BREBI M,PRISCILLA, GARCÍA M,PATRICIA, CAPURRO V,ITALO, GUZMÁN G,PABLO, SUÁREZ P,EUGENIO, OJEDA F,JOSÉ MANUEL, ROA S,JUAN CARLOS
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Alpha papilloma virus Genotype Uterine Cervical neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001200001
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spelling	oai:scielo:S0034-988720100012000012011-01-27Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterinoLÓPEZ M,JAIMEILI G,CARMEN GLORIABREBI M,PRISCILLAGARCÍA M,PATRICIACAPURRO V,ITALOGUZMÁN G,PABLOSUÁREZ P,EUGENIOOJEDA F,JOSÉ MANUELROA S,JUAN CARLOS Alpha papilloma virus Genotype Uterine Cervical neoplasms The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.11 20102010-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001200001es10.4067/S0034-98872010001200001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alpha papilloma virus Genotype Uterine Cervical neoplasms
spellingShingle	Alpha papilloma virus Genotype Uterine Cervical neoplasms LÓPEZ M,JAIME ILI G,CARMEN GLORIA BREBI M,PRISCILLA GARCÍA M,PATRICIA CAPURRO V,ITALO GUZMÁN G,PABLO SUÁREZ P,EUGENIO OJEDA F,JOSÉ MANUEL ROA S,JUAN CARLOS Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
description	The relationship between human papillomavirus (HPV) and uterine cervical cancer (UCC) is widely known and accepted. Aim: To determine the frequency of genotypes of HPV in cervical preneoplastic lesions in a high risk area of UCC. Material and Methods: Using a combination of PCR and Reverse Line Blot technique, 235 formalin fixed paraffin embedded samples, with diagnosis of low-grade squamous intraepithelial lesion (LSIL) or high-grade squamous intraepithelial lesion (HSIL) were genotyped. Results: HPV was detected in 61.2% of LSIL and 78.1% of HSIL. The main genotypes found were HPV 16, 18, 31, 45, 56 y 58. HPV 16 was the most common in both LSIL (18.1%) and HSIL (36.9%). HPV 16 or 18 were present in 25.1% and 47.1% of the LSIL and HSIL respectively. In both LSIL and HSIL, the predominant viral genotypes were those types classified as with a high oncogenic risk. Conclusions: HPV genotypes 16, 18, 31, 45, 56 y 58 were the most common in our series. HPV 16 and 18, viral types with high oncogenic risk and included in commercial vaccines, were found in 25.1% and 47.1% of LSIL and HSIL, respectively.
author	LÓPEZ M,JAIME ILI G,CARMEN GLORIA BREBI M,PRISCILLA GARCÍA M,PATRICIA CAPURRO V,ITALO GUZMÁN G,PABLO SUÁREZ P,EUGENIO OJEDA F,JOSÉ MANUEL ROA S,JUAN CARLOS
author_facet	LÓPEZ M,JAIME ILI G,CARMEN GLORIA BREBI M,PRISCILLA GARCÍA M,PATRICIA CAPURRO V,ITALO GUZMÁN G,PABLO SUÁREZ P,EUGENIO OJEDA F,JOSÉ MANUEL ROA S,JUAN CARLOS
author_sort	LÓPEZ M,JAIME
title	Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
title_short	Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
title_full	Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
title_fullStr	Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
title_full_unstemmed	Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
title_sort	detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001200001
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Detección y tipificación de virus papiloma humano en lesiones preneoplásicas de cuello uterino

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