Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica

Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (...

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Autores principales:	WINTER,JOSÉ LUIS, CASTRO,PABLO, MENESES,LUIS, CHALHUB,MÓNICA, VERDEJO,HUGO, GREIG,DOUGLAS, GABRIELLI,LUIGI, CHIONG,MARIO, CONCEPCIÓN,ROBERTO, MELLADO,ROSEMERIE, HERNÁNDEZ,CLAUDIA, URIBE,SERGIO, LAVANDERO,SERGIO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2010
Materias:	Creatine Heart failure Magnetic resonance spectroscopy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001300001
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spelling	oai:scielo:S0034-988720100013000012011-02-07Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémicaWINTER,JOSÉ LUISCASTRO,PABLOMENESES,LUISCHALHUB,MÓNICAVERDEJO,HUGOGREIG,DOUGLASGABRIELLI,LUIGICHIONG,MARIOCONCEPCIÓN,ROBERTOMELLADO,ROSEMERIEHERNÁNDEZ,CLAUDIAURIBE,SERGIOLAVANDERO,SERGIO Creatine Heart failure Magnetic resonance spectroscopy Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HF. Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in fve patients with non-ischemic heart failure, aged 58 ± 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 ± 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/ Cr index, among patients with heart failure, when compared with healthy controls (1.46 ± 1.21 and 5.96 ± 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 ± 2.66 and 1.80 ± 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.138 n.12 20102010-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001300001es10.4067/S0034-98872010001300001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Creatine Heart failure Magnetic resonance spectroscopy
spellingShingle	Creatine Heart failure Magnetic resonance spectroscopy WINTER,JOSÉ LUIS CASTRO,PABLO MENESES,LUIS CHALHUB,MÓNICA VERDEJO,HUGO GREIG,DOUGLAS GABRIELLI,LUIGI CHIONG,MARIO CONCEPCIÓN,ROBERTO MELLADO,ROSEMERIE HERNÁNDEZ,CLAUDIA URIBE,SERGIO LAVANDERO,SERGIO Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
description	Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by cardiomyocytes, associated with decreased deposits of high-energy phosphates (creatine phosphate/ creatine transporter). Magnetic resonance (MR) imaging allows a direct and noninvasive assessment of myocardial metabolites. Aim: To measure myocardial creatine and lipids by MR spectroscopy among patients with HF. Material and Methods: Cardiac MR spectroscopy (1.5 Tesla) with Hydrogen antenna and single voxel acquisition was performed in fve patients with non-ischemic heart failure, aged 58 ± 9.7 years, (60% males) and 5 healthy volunteers matched for age and sex. We analyzed the signals of creatine (Cr), lipids (L) and water (W) in the interventricular septum, establishing the water/lipid (W/L) and water/creatine (W/Cr) index to normalize the values obtained. Results: Among patients, left ventricular ejection fraction was 32 ± 6.9%, 60% were in functional capacity II, 60% had hypertension and one was diabetic. Spectroscopic curves showed a depletion of total Cr, evidenced by the W/ Cr index, among patients with heart failure, when compared with healthy controls (1.46 ± 1.21 and 5.96 ± 2.25 respectively, p < 0,05). Differences in myocardial lipid content, measured as the W/L index, were not significant (5.06 ± 2.66 and 1.80 ± 1.62 respectively, p = 0.08). Conclusions: Among patients with heart failure of non-ischemic etiology, there is a depletion of creatine levels measured by MR spectroscopy.
author	WINTER,JOSÉ LUIS CASTRO,PABLO MENESES,LUIS CHALHUB,MÓNICA VERDEJO,HUGO GREIG,DOUGLAS GABRIELLI,LUIGI CHIONG,MARIO CONCEPCIÓN,ROBERTO MELLADO,ROSEMERIE HERNÁNDEZ,CLAUDIA URIBE,SERGIO LAVANDERO,SERGIO
author_facet	WINTER,JOSÉ LUIS CASTRO,PABLO MENESES,LUIS CHALHUB,MÓNICA VERDEJO,HUGO GREIG,DOUGLAS GABRIELLI,LUIGI CHIONG,MARIO CONCEPCIÓN,ROBERTO MELLADO,ROSEMERIE HERNÁNDEZ,CLAUDIA URIBE,SERGIO LAVANDERO,SERGIO
author_sort	WINTER,JOSÉ LUIS
title	Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
title_short	Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
title_full	Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
title_fullStr	Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
title_full_unstemmed	Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
title_sort	determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica
publisher	Sociedad Médica de Santiago
publishDate	2010
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872010001300001
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Determinaciones de niveles de creatina y lípidos mediante espectroscopia por resonancia magnética en miocardio de pacientes con insuficiencia cardiaca no isquémica

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