Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile

Background: Simultaneous kidney and páncreas transplantation (SKPT) is the best alternative for end stage renal disease among patients with insulin dependent diabetes mellitus. Aim: To report our experience with SKPT. Material andMethods: Retrospective analysis ofl2 recipients of SKPT transplanted i...

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Autores principales:	ALBA,ANDREA, MORALES,JORGE, FERRARIO,MARIO, ZEHNDER,CARLOS, AGUILÓ,JORGE, ZAVALA,CARLOS, HERZOG,CRISTINA, CALABRAN,LORENA, CONTRERAS,LUIS, ESPINOZA,RICARDO, BUCKEL,ERWIN, FIERRO,JUAN ALBERTO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Kidney transplantation Organ transplantation Páncreas transplantation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100002
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spelling	oai:scielo:S0034-988720110001000022011-04-11Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en ChileALBA,ANDREAMORALES,JORGEFERRARIO,MARIOZEHNDER,CARLOSAGUILÓ,JORGEZAVALA,CARLOSHERZOG,CRISTINACALABRAN,LORENACONTRERAS,LUISESPINOZA,RICARDOBUCKEL,ERWINFIERRO,JUAN ALBERTO Kidney transplantation Organ transplantation Páncreas transplantation Background: Simultaneous kidney and páncreas transplantation (SKPT) is the best alternative for end stage renal disease among patients with insulin dependent diabetes mellitus. Aim: To report our experience with SKPT. Material andMethods: Retrospective analysis ofl2 recipients of SKPT transplanted in one center starting in 1994, with a meanfollow-upperiod of6.8years (2-15). Results: Eleven ofl2 recipients were in chronic hemodialysis before SKPT. Mean A, B, DR and HLA mismatch was 4.3. Mean preformed anti HLA antibodies was 3.3 %. Mean cold ischemia times for páncreas and kidney were 6 and 10 hours, respectively. In the first eight cases, the páncreas was drained to the bladder, and in the last four, an enteric drainage was performed. Eleven recipients were induced with antibodies, and maintenance immunosuppression consisted ofCyclosporine or Tacrolimusplus an antiproliferative agent. Ten year patient survival was 70 %. Páncreas and kidney survival, defined by insulin and dialysis independence, were 72 and 73% respectively. Fifty percent of recipients experienced acute graft rejection (cellular or humoral), with good response to treatment except in one case. Conclusions: This experience shows that SKPT is associated with an excellent patient survival associated to insulin and dialysis independence in 70% of patients at 10 years.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100002es10.4067/S0034-98872011000100002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Kidney transplantation Organ transplantation Páncreas transplantation
spellingShingle	Kidney transplantation Organ transplantation Páncreas transplantation ALBA,ANDREA MORALES,JORGE FERRARIO,MARIO ZEHNDER,CARLOS AGUILÓ,JORGE ZAVALA,CARLOS HERZOG,CRISTINA CALABRAN,LORENA CONTRERAS,LUIS ESPINOZA,RICARDO BUCKEL,ERWIN FIERRO,JUAN ALBERTO Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
description	Background: Simultaneous kidney and páncreas transplantation (SKPT) is the best alternative for end stage renal disease among patients with insulin dependent diabetes mellitus. Aim: To report our experience with SKPT. Material andMethods: Retrospective analysis ofl2 recipients of SKPT transplanted in one center starting in 1994, with a meanfollow-upperiod of6.8years (2-15). Results: Eleven ofl2 recipients were in chronic hemodialysis before SKPT. Mean A, B, DR and HLA mismatch was 4.3. Mean preformed anti HLA antibodies was 3.3 %. Mean cold ischemia times for páncreas and kidney were 6 and 10 hours, respectively. In the first eight cases, the páncreas was drained to the bladder, and in the last four, an enteric drainage was performed. Eleven recipients were induced with antibodies, and maintenance immunosuppression consisted ofCyclosporine or Tacrolimusplus an antiproliferative agent. Ten year patient survival was 70 %. Páncreas and kidney survival, defined by insulin and dialysis independence, were 72 and 73% respectively. Fifty percent of recipients experienced acute graft rejection (cellular or humoral), with good response to treatment except in one case. Conclusions: This experience shows that SKPT is associated with an excellent patient survival associated to insulin and dialysis independence in 70% of patients at 10 years.
author	ALBA,ANDREA MORALES,JORGE FERRARIO,MARIO ZEHNDER,CARLOS AGUILÓ,JORGE ZAVALA,CARLOS HERZOG,CRISTINA CALABRAN,LORENA CONTRERAS,LUIS ESPINOZA,RICARDO BUCKEL,ERWIN FIERRO,JUAN ALBERTO
author_facet	ALBA,ANDREA MORALES,JORGE FERRARIO,MARIO ZEHNDER,CARLOS AGUILÓ,JORGE ZAVALA,CARLOS HERZOG,CRISTINA CALABRAN,LORENA CONTRERAS,LUIS ESPINOZA,RICARDO BUCKEL,ERWIN FIERRO,JUAN ALBERTO
author_sort	ALBA,ANDREA
title	Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
title_short	Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
title_full	Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
title_fullStr	Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
title_full_unstemmed	Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile
title_sort	trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: experiencia de un centro en chile
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100002
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Trasplante simultáneo de páncreas y riñon en diabetes mellitus tipo 1: Experiencia de un centro en Chile

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