Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile

Background: The incidence oflymphoma increases enormously inpatients infecten with the human immunodeficiency virus (HIV). Aim: To describe the incidence, clinical and histológica! characteristics, treatments and survival of lymphomas associated with HTV infection. Material and Methods: Retrospectiv...

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Autores principales:	ROJAS H,CHRISTINE, MERINO M,CARLOS, GHIRINGHELLI M,JUAN PABLO, RODRÍGUEZ A,JOSÉ RAMÓN, MARTÍNEZ L,FELIPE, JENSEN R,WERNER
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Anti-retroviral agents HIV lymphoma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100004
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spelling	oai:scielo:S0034-988720110001000042011-04-11Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, ChileROJAS H,CHRISTINEMERINO M,CARLOSGHIRINGHELLI M,JUAN PABLORODRÍGUEZ A,JOSÉ RAMÓNMARTÍNEZ L,FELIPEJENSEN R,WERNER Anti-retroviral agents HIV lymphoma Background: The incidence oflymphoma increases enormously inpatients infecten with the human immunodeficiency virus (HIV). Aim: To describe the incidence, clinical and histológica! characteristics, treatments and survival of lymphomas associated with HTV infection. Material and Methods: Retrospective review of medical records ofpatients with HIV and lymphoma, treated in a public hospital, between January 2001 and June 2009. Results: Twenty-two mole patients were included but 14 had immunohistochemical confirmation ofthe lymphoma. The accumulated incidence for thisperiod was 2.8%. The median age at lymphoma diagnosis was 39.5 years. Twelvepatients (86%) had non-Hodgkin lymphoma (NHI) and two (14%) Hodgkin lymphoma. The main pathological type of non-Hodgkin lymphomas was diffuse large B cell in seven cases (50%). The mean CD4 cell count and viral load were 83 cell/mm³ (33.5-113.5) and 26.000 RNA copies/ml (1210-196500), respectively Twelve patients (86%) had B type symptoms of lymphoma at the moment of diagnosis. Eleven patients (29%) received chemotherapy with or without radiotherapy, onepatient (7%) received radiotherapy alone and two patients (14%) received palliative symptomatic treatment. Six cases (43%) received highly active antiretroviral therapy simultaneously with chemotherapy. Global mortality in this series was 57% (8patients) with a median survival time of 5.8 months (2.6-26.2). Conclusions: In this series ofpatients infected with HIV, a predominance of aggressive histológica! subtypes of lymphomas and low complete remission rates, were observed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100004es10.4067/S0034-98872011000100004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anti-retroviral agents HIV lymphoma
spellingShingle	Anti-retroviral agents HIV lymphoma ROJAS H,CHRISTINE MERINO M,CARLOS GHIRINGHELLI M,JUAN PABLO RODRÍGUEZ A,JOSÉ RAMÓN MARTÍNEZ L,FELIPE JENSEN R,WERNER Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
description	Background: The incidence oflymphoma increases enormously inpatients infecten with the human immunodeficiency virus (HIV). Aim: To describe the incidence, clinical and histológica! characteristics, treatments and survival of lymphomas associated with HTV infection. Material and Methods: Retrospective review of medical records ofpatients with HIV and lymphoma, treated in a public hospital, between January 2001 and June 2009. Results: Twenty-two mole patients were included but 14 had immunohistochemical confirmation ofthe lymphoma. The accumulated incidence for thisperiod was 2.8%. The median age at lymphoma diagnosis was 39.5 years. Twelvepatients (86%) had non-Hodgkin lymphoma (NHI) and two (14%) Hodgkin lymphoma. The main pathological type of non-Hodgkin lymphomas was diffuse large B cell in seven cases (50%). The mean CD4 cell count and viral load were 83 cell/mm³ (33.5-113.5) and 26.000 RNA copies/ml (1210-196500), respectively Twelve patients (86%) had B type symptoms of lymphoma at the moment of diagnosis. Eleven patients (29%) received chemotherapy with or without radiotherapy, onepatient (7%) received radiotherapy alone and two patients (14%) received palliative symptomatic treatment. Six cases (43%) received highly active antiretroviral therapy simultaneously with chemotherapy. Global mortality in this series was 57% (8patients) with a median survival time of 5.8 months (2.6-26.2). Conclusions: In this series ofpatients infected with HIV, a predominance of aggressive histológica! subtypes of lymphomas and low complete remission rates, were observed.
author	ROJAS H,CHRISTINE MERINO M,CARLOS GHIRINGHELLI M,JUAN PABLO RODRÍGUEZ A,JOSÉ RAMÓN MARTÍNEZ L,FELIPE JENSEN R,WERNER
author_facet	ROJAS H,CHRISTINE MERINO M,CARLOS GHIRINGHELLI M,JUAN PABLO RODRÍGUEZ A,JOSÉ RAMÓN MARTÍNEZ L,FELIPE JENSEN R,WERNER
author_sort	ROJAS H,CHRISTINE
title	Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
title_short	Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
title_full	Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
title_fullStr	Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
title_full_unstemmed	Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile
title_sort	linfomas asociados a infección por virus de inmunodeficiencia humana: experiencia de un centro hospitalario de la v región, chile
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100004
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Linfomas asociados a infección por Virus de Inmunodeficiencia Humana: Experiencia de un centro hospitalario de la V región, Chile

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