Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentia...
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Sociedad Médica de Santiago
2011
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oai:scielo:S0034-988720110001000132011-04-11Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?IRARRÁZAVAL O,MARÍA ELISA Antidepressive agents Breast neoplasms Tamoxifen Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentially inhibit cytochrome P450 2D6, required to actívate tamoxifen, interfering with its action. Although there is not a clear cut directive on the subject, it is nowadays recommended to treat women with antidepressants with the lower cytochrome P450 2D6 inhibition potential to avoid apossible antagonism that may reduce tamoxifen s prevention of breast cáncer recurrence at least in some patients with CYP2D6 genetic variation. The recommended antidepressants are desvenlafaxine, milnacipran, venlafaxin, escitalopram and citalopram.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100013es10.4067/S0034-98872011000100013 |
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Scielo Chile |
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Scielo Chile |
language |
Spanish / Castilian |
topic |
Antidepressive agents Breast neoplasms Tamoxifen |
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Antidepressive agents Breast neoplasms Tamoxifen IRARRÁZAVAL O,MARÍA ELISA Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
description |
Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentially inhibit cytochrome P450 2D6, required to actívate tamoxifen, interfering with its action. Although there is not a clear cut directive on the subject, it is nowadays recommended to treat women with antidepressants with the lower cytochrome P450 2D6 inhibition potential to avoid apossible antagonism that may reduce tamoxifen s prevention of breast cáncer recurrence at least in some patients with CYP2D6 genetic variation. The recommended antidepressants are desvenlafaxine, milnacipran, venlafaxin, escitalopram and citalopram. |
author |
IRARRÁZAVAL O,MARÍA ELISA |
author_facet |
IRARRÁZAVAL O,MARÍA ELISA |
author_sort |
IRARRÁZAVAL O,MARÍA ELISA |
title |
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
title_short |
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
title_full |
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
title_fullStr |
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
title_full_unstemmed |
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama? |
title_sort |
tamoxifeno y antidepresivos: ¿antagonistas en la prevención del cáncer de mama? |
publisher |
Sociedad Médica de Santiago |
publishDate |
2011 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100013 |
work_keys_str_mv |
AT irarrazavalomariaelisa tamoxifenoyantidepresivosantagonistasenlaprevenciondelcancerdemama |
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1718436548664360960 |