Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?

Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentia...

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Autor principal: IRARRÁZAVAL O,MARÍA ELISA
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2011
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100013
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spelling oai:scielo:S0034-988720110001000132011-04-11Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?IRARRÁZAVAL O,MARÍA ELISA Antidepressive agents Breast neoplasms Tamoxifen Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentially inhibit cytochrome P450 2D6, required to actívate tamoxifen, interfering with its action. Although there is not a clear cut directive on the subject, it is nowadays recommended to treat women with antidepressants with the lower cytochrome P450 2D6 inhibition potential to avoid apossible antagonism that may reduce tamoxifen s prevention of breast cáncer recurrence at least in some patients with CYP2D6 genetic variation. The recommended antidepressants are desvenlafaxine, milnacipran, venlafaxin, escitalopram and citalopram.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.1 20112011-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100013es10.4067/S0034-98872011000100013
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Antidepressive agents
Breast neoplasms
Tamoxifen
spellingShingle Antidepressive agents
Breast neoplasms
Tamoxifen
IRARRÁZAVAL O,MARÍA ELISA
Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
description Tamoxifen is used as an adjuvant therapy to reduce breast cáncer recurrence among women with estrogenreceptor positive tumors. Antidepressants are also com-monly used in such women, to treat depression or to manage hotflush.es, afrequent tamoxifen secondary effect. Some antidepressants couldpotentially inhibit cytochrome P450 2D6, required to actívate tamoxifen, interfering with its action. Although there is not a clear cut directive on the subject, it is nowadays recommended to treat women with antidepressants with the lower cytochrome P450 2D6 inhibition potential to avoid apossible antagonism that may reduce tamoxifen s prevention of breast cáncer recurrence at least in some patients with CYP2D6 genetic variation. The recommended antidepressants are desvenlafaxine, milnacipran, venlafaxin, escitalopram and citalopram.
author IRARRÁZAVAL O,MARÍA ELISA
author_facet IRARRÁZAVAL O,MARÍA ELISA
author_sort IRARRÁZAVAL O,MARÍA ELISA
title Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
title_short Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
title_full Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
title_fullStr Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
title_full_unstemmed Tamoxifeno y antidepresivos: ¿Antagonistas en la prevención del cáncer de mama?
title_sort tamoxifeno y antidepresivos: ¿antagonistas en la prevención del cáncer de mama?
publisher Sociedad Médica de Santiago
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000100013
work_keys_str_mv AT irarrazavalomariaelisa tamoxifenoyantidepresivosantagonistasenlaprevenciondelcancerdemama
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