Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura

Hemophagocytic syndrome (HS) is a severe hyper inflammatory condition whose cardinal symptoms are prolonged fever, cytopenia, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. The clinical course resembles sepsis, sharing similar physiopathological features....

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Autores principales:	YOUNG,PABLO, PERONI,JOSE, FINN,BÁRBARA C, VENDITTI,JULIO E, PREITI,VERÓNICA, BULLORSKY,EDUARDO, BRUETMAN,JULIO E
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Adrenal cortex hormones Leukopenia Lymphohisiocytosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200013
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spelling	oai:scielo:S0034-988720110002000132011-08-01Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literaturaYOUNG,PABLOPERONI,JOSEFINN,BÁRBARA CVENDITTI,JULIO EPREITI,VERÓNICABULLORSKY,EDUARDOBRUETMAN,JULIO E Adrenal cortex hormones Leukopenia Lymphohisiocytosis Hemophagocytic syndrome (HS) is a severe hyper inflammatory condition whose cardinal symptoms are prolonged fever, cytopenia, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. The clinical course resembles sepsis, sharing similar physiopathological features. We report four patients with the syndrome. A 61-year-old female presenting with fever and pleuritic pain. During the course of the disease, a pancytopenia was detected and a bone marrow aspiration was suggestive of HS. The patient was treated with cyclosporine and steroids with a good response. A 61-year-old male with fever and pancytopenia and a bone marrow aspirate suggestive of HS. The patient did not respond to treatment and died. A 23-year-old male with fever, pancytopenia and positive Hanta virus antibodies. A bone marrow aspirate was suggestive of HS. The patient recovered without any treatment. A 72-year-old male admitted with the diagnosis of pneumonia, that developed a progressive pancytopenia and bone marrow aspirate was suggestive of HS. A bronchoalveolar lavage showed the presence of Acinetobacter baumanii. Despite treatment with methylprednisolone and gammaglobulin, the patient died. Awareness of the clinical symptoms and of the diagnostic criteria of HS is important to start life-saving therapy in time.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.2 20112011-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200013es10.4067/S0034-98872011000200013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adrenal cortex hormones Leukopenia Lymphohisiocytosis
spellingShingle	Adrenal cortex hormones Leukopenia Lymphohisiocytosis YOUNG,PABLO PERONI,JOSE FINN,BÁRBARA C VENDITTI,JULIO E PREITI,VERÓNICA BULLORSKY,EDUARDO BRUETMAN,JULIO E Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
description	Hemophagocytic syndrome (HS) is a severe hyper inflammatory condition whose cardinal symptoms are prolonged fever, cytopenia, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages. The clinical course resembles sepsis, sharing similar physiopathological features. We report four patients with the syndrome. A 61-year-old female presenting with fever and pleuritic pain. During the course of the disease, a pancytopenia was detected and a bone marrow aspiration was suggestive of HS. The patient was treated with cyclosporine and steroids with a good response. A 61-year-old male with fever and pancytopenia and a bone marrow aspirate suggestive of HS. The patient did not respond to treatment and died. A 23-year-old male with fever, pancytopenia and positive Hanta virus antibodies. A bone marrow aspirate was suggestive of HS. The patient recovered without any treatment. A 72-year-old male admitted with the diagnosis of pneumonia, that developed a progressive pancytopenia and bone marrow aspirate was suggestive of HS. A bronchoalveolar lavage showed the presence of Acinetobacter baumanii. Despite treatment with methylprednisolone and gammaglobulin, the patient died. Awareness of the clinical symptoms and of the diagnostic criteria of HS is important to start life-saving therapy in time.
author	YOUNG,PABLO PERONI,JOSE FINN,BÁRBARA C VENDITTI,JULIO E PREITI,VERÓNICA BULLORSKY,EDUARDO BRUETMAN,JULIO E
author_facet	YOUNG,PABLO PERONI,JOSE FINN,BÁRBARA C VENDITTI,JULIO E PREITI,VERÓNICA BULLORSKY,EDUARDO BRUETMAN,JULIO E
author_sort	YOUNG,PABLO
title	Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
title_short	Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
title_full	Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
title_fullStr	Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
title_full_unstemmed	Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura
title_sort	síndrome hematofagocítico: reporte de cuatro casos y revisión de la literatura
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200013
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Síndrome hematofagocítico: Reporte de cuatro casos y revisión de la literatura

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