Hemocianinas, una herramienta inmunológica de la biomedicina actual

Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immuno-genicity. Therefore they are ideal non-specific immunostimulants to treat some types of cancer. They are used as an alternative therapy for s...

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Autores principales:	DEL CAMPO,MIGUEL, ARANCIBIA,SERGIO, NOVA,ESTEBAN, SALAZAR,FABIÁN, GONZÁLEZ,ANDREA, MOLTEDO,BRUNO, DE IOANNES,PABLO, FERREIRA,JORGE, MANUBENS,AUGUSTO, BECKER,MARÍA INÉS
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Adjuvants, immunologic Hemocyanin Urinary bladder neoplasm
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200015
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spelling	oai:scielo:S0034-988720110002000152011-08-01Hemocianinas, una herramienta inmunológica de la biomedicina actualDEL CAMPO,MIGUELARANCIBIA,SERGIONOVA,ESTEBANSALAZAR,FABIÁNGONZÁLEZ,ANDREAMOLTEDO,BRUNODE IOANNES,PABLOFERREIRA,JORGEMANUBENS,AUGUSTOBECKER,MARÍA INÉS Adjuvants, immunologic Hemocyanin Urinary bladder neoplasm Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immuno-genicity. Therefore they are ideal non-specific immunostimulants to treat some types of cancer. They are used as an alternative therapy for superficial urinary bladder cancer (SBC), that has been traditionally treated with Bacillus Calmette-Guerin (BCG). In contrast to BCG, hemocyanins do not cause side-effects, making them ideal for long-term repetitive treatments. Hemocyanins have also been exploited as carriers to develop antibodies against hapten molecules and peptides, as carrier-adjuvants for cutting-edge vaccines against cancer, drug addiction, and infectious diseases and in the diagnosis of parasitic diseases, such as Schistosomiasis. The hemocyanin from Megathura crenulata, also known as keyhole limpet hemocyanin (KLH), has been used for over thirty years for the purposes described above. More recently, hemoc yanin from the Chilean mollusk Concholepas concholepas (CCH) has proved to be a reliable alternative to KLH, either as carrier protein, and as a likely alternative for the immunotherapy of SBC. Despite KLH and CCH differ significantly in their origin and structure, we have demonstrated that both hemocyanins stimulate the immune system of mammals in a similar way by inducing a potent Thl-polarized cellular and humoral response.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.2 20112011-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200015es10.4067/S0034-98872011000200015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adjuvants, immunologic Hemocyanin Urinary bladder neoplasm
spellingShingle	Adjuvants, immunologic Hemocyanin Urinary bladder neoplasm DEL CAMPO,MIGUEL ARANCIBIA,SERGIO NOVA,ESTEBAN SALAZAR,FABIÁN GONZÁLEZ,ANDREA MOLTEDO,BRUNO DE IOANNES,PABLO FERREIRA,JORGE MANUBENS,AUGUSTO BECKER,MARÍA INÉS Hemocianinas, una herramienta inmunológica de la biomedicina actual
description	Hemocyanins, the giant oxygen transporter glycoproteins of diverse mollusks, are xenogenic to the mammalian immune system and they display a remarkable immuno-genicity. Therefore they are ideal non-specific immunostimulants to treat some types of cancer. They are used as an alternative therapy for superficial urinary bladder cancer (SBC), that has been traditionally treated with Bacillus Calmette-Guerin (BCG). In contrast to BCG, hemocyanins do not cause side-effects, making them ideal for long-term repetitive treatments. Hemocyanins have also been exploited as carriers to develop antibodies against hapten molecules and peptides, as carrier-adjuvants for cutting-edge vaccines against cancer, drug addiction, and infectious diseases and in the diagnosis of parasitic diseases, such as Schistosomiasis. The hemocyanin from Megathura crenulata, also known as keyhole limpet hemocyanin (KLH), has been used for over thirty years for the purposes described above. More recently, hemoc yanin from the Chilean mollusk Concholepas concholepas (CCH) has proved to be a reliable alternative to KLH, either as carrier protein, and as a likely alternative for the immunotherapy of SBC. Despite KLH and CCH differ significantly in their origin and structure, we have demonstrated that both hemocyanins stimulate the immune system of mammals in a similar way by inducing a potent Thl-polarized cellular and humoral response.
author	DEL CAMPO,MIGUEL ARANCIBIA,SERGIO NOVA,ESTEBAN SALAZAR,FABIÁN GONZÁLEZ,ANDREA MOLTEDO,BRUNO DE IOANNES,PABLO FERREIRA,JORGE MANUBENS,AUGUSTO BECKER,MARÍA INÉS
author_facet	DEL CAMPO,MIGUEL ARANCIBIA,SERGIO NOVA,ESTEBAN SALAZAR,FABIÁN GONZÁLEZ,ANDREA MOLTEDO,BRUNO DE IOANNES,PABLO FERREIRA,JORGE MANUBENS,AUGUSTO BECKER,MARÍA INÉS
author_sort	DEL CAMPO,MIGUEL
title	Hemocianinas, una herramienta inmunológica de la biomedicina actual
title_short	Hemocianinas, una herramienta inmunológica de la biomedicina actual
title_full	Hemocianinas, una herramienta inmunológica de la biomedicina actual
title_fullStr	Hemocianinas, una herramienta inmunológica de la biomedicina actual
title_full_unstemmed	Hemocianinas, una herramienta inmunológica de la biomedicina actual
title_sort	hemocianinas, una herramienta inmunológica de la biomedicina actual
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000200015
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Hemocianinas, una herramienta inmunológica de la biomedicina actual

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