Aumento del daño en el ADN espermático en varones mayores de 40 años

Background: There is an association between aging ana an increased number ofsperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material andMethods: Sixty two volunteers provided semen for analysis. These were separated in a group aged le...

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Autores principales:	Horta,Fabrizzio, Madariaga,Marcia, García,Alejandra, Hartel,Steffen, Smith,Rosita
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Aging DNA fragmentation Spermatozoa
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300004
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spelling	oai:scielo:S0034-988720110003000042011-08-25Aumento del daño en el ADN espermático en varones mayores de 40 añosHorta,FabrizzioMadariaga,MarciaGarcía,AlejandraHartel,SteffenSmith,Rosita Aging DNA fragmentation Spermatozoa Background: There is an association between aging ana an increased number ofsperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material andMethods: Sixty two volunteers provided semen for analysis. These were separated in a group aged less than forty years and a second group aged more than forty years. Sperm DNA fragmentation was studied by TÚNEL (terminal deoxynucleotidyl transferase-mediated2'-deoxyuridine 5'-triphosphate nick end-labeling) and SCD (sperm chromatin dispersión test) assays. Results: Compared with theiryounger counterparts, patients aged more than 40years had a higher proportion ofsperms with DNA fragmentation by TÚNEL (20 ±1.3 and24 ± 1.9% respectively, p < 0.05) and SCD (22 ± 1.4 and26 ± 1.6% respectively, p < 0.05). The results ofboth assays had a correlation coefficientofO.8. No differences between groups were observed for other seminal parameters. Conclusions: Sperm DNA fragmentation increases with age in males.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.3 20112011-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300004es10.4067/S0034-98872011000300004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aging DNA fragmentation Spermatozoa
spellingShingle	Aging DNA fragmentation Spermatozoa Horta,Fabrizzio Madariaga,Marcia García,Alejandra Hartel,Steffen Smith,Rosita Aumento del daño en el ADN espermático en varones mayores de 40 años
description	Background: There is an association between aging ana an increased number ofsperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material andMethods: Sixty two volunteers provided semen for analysis. These were separated in a group aged less than forty years and a second group aged more than forty years. Sperm DNA fragmentation was studied by TÚNEL (terminal deoxynucleotidyl transferase-mediated2'-deoxyuridine 5'-triphosphate nick end-labeling) and SCD (sperm chromatin dispersión test) assays. Results: Compared with theiryounger counterparts, patients aged more than 40years had a higher proportion ofsperms with DNA fragmentation by TÚNEL (20 ±1.3 and24 ± 1.9% respectively, p < 0.05) and SCD (22 ± 1.4 and26 ± 1.6% respectively, p < 0.05). The results ofboth assays had a correlation coefficientofO.8. No differences between groups were observed for other seminal parameters. Conclusions: Sperm DNA fragmentation increases with age in males.
author	Horta,Fabrizzio Madariaga,Marcia García,Alejandra Hartel,Steffen Smith,Rosita
author_facet	Horta,Fabrizzio Madariaga,Marcia García,Alejandra Hartel,Steffen Smith,Rosita
author_sort	Horta,Fabrizzio
title	Aumento del daño en el ADN espermático en varones mayores de 40 años
title_short	Aumento del daño en el ADN espermático en varones mayores de 40 años
title_full	Aumento del daño en el ADN espermático en varones mayores de 40 años
title_fullStr	Aumento del daño en el ADN espermático en varones mayores de 40 años
title_full_unstemmed	Aumento del daño en el ADN espermático en varones mayores de 40 años
title_sort	aumento del daño en el adn espermático en varones mayores de 40 años
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300004
work_keys_str_mv	AT hortafabrizzio aumentodeldanoeneladnespermaticoenvaronesmayoresde40anos AT madariagamarcia aumentodeldanoeneladnespermaticoenvaronesmayoresde40anos AT garciaalejandra aumentodeldanoeneladnespermaticoenvaronesmayoresde40anos AT hartelsteffen aumentodeldanoeneladnespermaticoenvaronesmayoresde40anos AT smithrosita aumentodeldanoeneladnespermaticoenvaronesmayoresde40anos
_version_	1718436555699257344

Aumento del daño en el ADN espermático en varones mayores de 40 años

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