Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal

Background: Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD). Aim: To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material and Methods: Serum calcium and...

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Autores principales:	Delucchi,Angela, Alarcón,Claudia, Cano,Francisco, Lillo,Ana María, Guerrero,José Luis, Azócar,Marta, Abarzúa,Carolina, Muñoz,María José, Iñiguez,Germán
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Child Renal insufficiency chronic Vitamin D
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300008
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spelling	oai:scielo:S0034-988720110003000082011-08-25Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renalDelucchi,AngelaAlarcón,ClaudiaCano,FranciscoLillo,Ana MaríaGuerrero,José LuisAzócar,MartaAbarzúa,CarolinaMuñoz,María JoséIñiguez,Germán Child Renal insufficiency chronic Vitamin D Background: Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD). Aim: To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material and Methods: Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51% females). Results: Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD: 21 ± 16.8, PD: 18.9 ± 8.5, Tx: 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04). Conclusions: Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.3 20112011-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300008es10.4067/S0034-98872011000300008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Child Renal insufficiency chronic Vitamin D
spellingShingle	Child Renal insufficiency chronic Vitamin D Delucchi,Angela Alarcón,Claudia Cano,Francisco Lillo,Ana María Guerrero,José Luis Azócar,Marta Abarzúa,Carolina Muñoz,María José Iñiguez,Germán Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
description	Background: Hypovitaminosis D has a high prevalence among patients with chronic kidney disease (CKD). Aim: To determine the prevalence of 25 hydroxy vitamin D (25(OH) D) insufficiency and deficiency in pediatric patients on dialysis and kidney transplantation. Material and Methods: Serum calcium and phosphorus, parathormone (PTH), alkaline phosphatases and 25 (OH)D were measured in 13 children on hemodialysis (HD), 18 on peritoneal dialysis (PD) and 53 that received an allograft (Tx), aged 9.8 ± 4.6 years (51% females). Results: Fifty four percent of patients had height Z score less than -1.88. Patients on HD had the lowest values. The average time of replacement therapy was 2.9 ± 2.8 years. Mean 25(OH)D levels in all was 18.7 ± 10.7ng/ml (HD: 21 ± 16.8, PD: 18.9 ± 8.5, Tx: 18.1 ± 9.72 ng/ml). Eighty eight percent of patients had levels below 30 ng/ml. Mean of serum calcium was 9.5 ± 0.64 mg/dl, serum phosphorus 5.03 ± 1.02 mg/dl, calcium-phosphorus product 48 ± 11.8 mg/dl and alkaline phosphatases 300.5 ± 171.3 IU/L. Average PTH values in dialyzed and Tx patients were 724.6 ± 640.5 and 107.7 ± 56.2 pg/ml, respectively (p < 0.001). A positive correlation between 25 (OH) D and calcium levels among PD patients was observed (r = 0.490, p = 0.04). Conclusions: Hypovitaminosis D is highly prevalent among children on renal substitution therapy, regardless of the type of therapy used and the stage of renal failure.
author	Delucchi,Angela Alarcón,Claudia Cano,Francisco Lillo,Ana María Guerrero,José Luis Azócar,Marta Abarzúa,Carolina Muñoz,María José Iñiguez,Germán
author_facet	Delucchi,Angela Alarcón,Claudia Cano,Francisco Lillo,Ana María Guerrero,José Luis Azócar,Marta Abarzúa,Carolina Muñoz,María José Iñiguez,Germán
author_sort	Delucchi,Angela
title	Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
title_short	Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
title_full	Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
title_fullStr	Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
title_full_unstemmed	Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal
title_sort	hipovitaminosis d en pacientes pediátricos en terapia de sustitución renal
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300008
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Hipovitaminosis D en pacientes pediátricos en terapia de sustitución renal

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