El embarazo humano: paradigma biológico de tolerancia y adaptación

This review analyses the changes in immunological tolerance, and the systemic and local hemodynamic changes observed along human pregnancy. To underscore the conceptual importance of tolerance and adaptation the background isprovided by the two main advocates ofthese ideas: Gandhi and Darwin. The co...

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Autor principal:	Valdés S,Gloria
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Adaptation physiologic Immune tolerance Maternal fetal exchange Pregnancy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300019
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spelling	oai:scielo:S0034-988720110003000192011-08-25El embarazo humano: paradigma biológico de tolerancia y adaptaciónValdés S,Gloria Adaptation physiologic Immune tolerance Maternal fetal exchange Pregnancy This review analyses the changes in immunological tolerance, and the systemic and local hemodynamic changes observed along human pregnancy. To underscore the conceptual importance of tolerance and adaptation the background isprovided by the two main advocates ofthese ideas: Gandhi and Darwin. The cognate factors that determine immunological tolerance (IT), systemic (SA) and local adaptation (LA) are múltiple; IT = desensitisation to paternal antigens, absence of HLA-A, roles of HLA-G, natural killer cells and their receptors; SA = decreased vascular resistance, plasma volume expansión, increased cardiac output and plasma renin activity; LA = prostacyclin, nitric oxide, kallikrein-kinin system, vasodilator arm of the renin angiotensin system, vascular endothelial growth factor (VEGF). A possible role of vasodilators in the crucial process of trophoblast invasión and uterine artery transformation is supported. The relevance ofan adequate adaptation to pregnancy is highlighted not only by the intragestational complications derivedfrom a defective process, such as intrauterine growth restriction, preterm birth, and preeclampsia -its foremost expression- but also by the long term cardiovascular complications ofthe mother and her offspring.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.3 20112011-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300019es10.4067/S0034-98872011000300019
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adaptation physiologic Immune tolerance Maternal fetal exchange Pregnancy
spellingShingle	Adaptation physiologic Immune tolerance Maternal fetal exchange Pregnancy Valdés S,Gloria El embarazo humano: paradigma biológico de tolerancia y adaptación
description	This review analyses the changes in immunological tolerance, and the systemic and local hemodynamic changes observed along human pregnancy. To underscore the conceptual importance of tolerance and adaptation the background isprovided by the two main advocates ofthese ideas: Gandhi and Darwin. The cognate factors that determine immunological tolerance (IT), systemic (SA) and local adaptation (LA) are múltiple; IT = desensitisation to paternal antigens, absence of HLA-A, roles of HLA-G, natural killer cells and their receptors; SA = decreased vascular resistance, plasma volume expansión, increased cardiac output and plasma renin activity; LA = prostacyclin, nitric oxide, kallikrein-kinin system, vasodilator arm of the renin angiotensin system, vascular endothelial growth factor (VEGF). A possible role of vasodilators in the crucial process of trophoblast invasión and uterine artery transformation is supported. The relevance ofan adequate adaptation to pregnancy is highlighted not only by the intragestational complications derivedfrom a defective process, such as intrauterine growth restriction, preterm birth, and preeclampsia -its foremost expression- but also by the long term cardiovascular complications ofthe mother and her offspring.
author	Valdés S,Gloria
author_facet	Valdés S,Gloria
author_sort	Valdés S,Gloria
title	El embarazo humano: paradigma biológico de tolerancia y adaptación
title_short	El embarazo humano: paradigma biológico de tolerancia y adaptación
title_full	El embarazo humano: paradigma biológico de tolerancia y adaptación
title_fullStr	El embarazo humano: paradigma biológico de tolerancia y adaptación
title_full_unstemmed	El embarazo humano: paradigma biológico de tolerancia y adaptación
title_sort	el embarazo humano: paradigma biológico de tolerancia y adaptación
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000300019
work_keys_str_mv	AT valdessgloria elembarazohumanoparadigmabiologicodetoleranciayadaptacion
_version_	1718436559209889792

El embarazo humano: paradigma biológico de tolerancia y adaptación

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