Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC

Background: Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor effcacy of targeted therapy against cancer in the central nervous system. Aim: To analyze the percentage o...

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Autores principales:	Quezada,Claudia, Peigñan,Lilia, Segura,Rodrigo, Riquelme,Francisco, Melo,Rómulo, Rojas Z,David, Ayach,Freddy, San Martín,Rody, Cárcamo,Juan Guillermo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Drug resistance neoplasm Glioblastoma Multidrug resistance-associated proteins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400001
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spelling	oai:scielo:S0034-988720110004000012011-08-25Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABCQuezada,ClaudiaPeigñan,LiliaSegura,RodrigoRiquelme,FranciscoMelo,RómuloRojas Z,DavidAyach,FreddySan Martín,RodyCárcamo,Juan Guillermo Drug resistance neoplasm Glioblastoma Multidrug resistance-associated proteins Background: Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor effcacy of targeted therapy against cancer in the central nervous system. Aim: To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters. Materials and Methods: Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA. Results: The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies. Conclusions: We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.4 20112011-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400001es10.4067/S0034-98872011000400001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Drug resistance neoplasm Glioblastoma Multidrug resistance-associated proteins
spellingShingle	Drug resistance neoplasm Glioblastoma Multidrug resistance-associated proteins Quezada,Claudia Peigñan,Lilia Segura,Rodrigo Riquelme,Francisco Melo,Rómulo Rojas Z,David Ayach,Freddy San Martín,Rody Cárcamo,Juan Guillermo Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
description	Background: Mortality rate is dramatically high in high grade brain tumors. The presence of multiple drug resistance transporters in glioblastoma multiforme, has contributed largely to the poor effcacy of targeted therapy against cancer in the central nervous system. Aim: To analyze the percentage of survival and mortality of patients with glioblastoma multiforme in a cohort of patients in Chile and to co-rrelate the chemo-resistance of these cells with the expression level of multiple drug resistance transporters. Materials and Methods: Eighteen biopsies of glioblastoma multiforme were obtained from patients at the Institute of Neurosurgery Dr. Asenjo (INCA). The tumor cells were obtained from primary cultures and the expression and activity of multiple drug resistance transporters was assessed by RT-PCR and immunohistochemistry. Population-based study was performed using the databases of the Department of Neurosurgery of INCA. Results: The number of patients with glioblastoma multiforme increased between 2007 and 2009, from 3.5% to 7.9% of total brain tumors. Mortality of these tumors is 90 % at three years. A high expression and activity of the multiple drugs resistance associated protein 1 (Mrp1) transporter was observed in primary cultures of biopsies. Conclusions: We propose that Mrp1 activity is responsible for the chemo-resistance of the glioblastoma multiforme and inhibition of this transporter could represent a plausible strategy for the treatment.
author	Quezada,Claudia Peigñan,Lilia Segura,Rodrigo Riquelme,Francisco Melo,Rómulo Rojas Z,David Ayach,Freddy San Martín,Rody Cárcamo,Juan Guillermo
author_facet	Quezada,Claudia Peigñan,Lilia Segura,Rodrigo Riquelme,Francisco Melo,Rómulo Rojas Z,David Ayach,Freddy San Martín,Rody Cárcamo,Juan Guillermo
author_sort	Quezada,Claudia
title	Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
title_short	Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
title_full	Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
title_fullStr	Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
title_full_unstemmed	Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC
title_sort	glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores abc
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400001
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Glioblastoma multiforme y estudio de la resistencia a la quimioterapia mediada por transportadores ABC

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