Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca

Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart failure. However, there is no consensus about its action in cardiovascular disease...

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Autores principales:	Alcaíno,Hernán, Greig,Douglas, Castro,Pablo, Verdejo,Hugo, Mellado,Rosemarie, García,Lorena, Díaz-Araya,Guillermo, Quiroga,Clara, Chiong,Mario, Lavandero,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Heart failure Oxidative stress Uric acid
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400014
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spelling	oai:scielo:S0034-988720110004000142011-08-25Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiacaAlcaíno,HernánGreig,DouglasCastro,PabloVerdejo,HugoMellado,RosemarieGarcía,LorenaDíaz-Araya,GuillermoQuiroga,ClaraChiong,MarioLavandero,Sergio Heart failure Oxidative stress Uric acid Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart failure. However, there is no consensus about its action in cardiovascular disease. Serum uric acid would have a protective antioxidant activity. This action could help to reduce or counteract the processes that cause or appear as a result of heart failure. However, these protective properties would vanish in the intracellular environment or in highly hydrophobic areas such as atherosclerotic plaques and adipose tissue. This review discusses the paradoxical action of uric acid in the pathophysiology of heart failure.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.4 20112011-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400014es10.4067/S0034-98872011000400014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Heart failure Oxidative stress Uric acid
spellingShingle	Heart failure Oxidative stress Uric acid Alcaíno,Hernán Greig,Douglas Castro,Pablo Verdejo,Hugo Mellado,Rosemarie García,Lorena Díaz-Araya,Guillermo Quiroga,Clara Chiong,Mario Lavandero,Sergio Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
description	Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart failure. However, there is no consensus about its action in cardiovascular disease. Serum uric acid would have a protective antioxidant activity. This action could help to reduce or counteract the processes that cause or appear as a result of heart failure. However, these protective properties would vanish in the intracellular environment or in highly hydrophobic areas such as atherosclerotic plaques and adipose tissue. This review discusses the paradoxical action of uric acid in the pathophysiology of heart failure.
author	Alcaíno,Hernán Greig,Douglas Castro,Pablo Verdejo,Hugo Mellado,Rosemarie García,Lorena Díaz-Araya,Guillermo Quiroga,Clara Chiong,Mario Lavandero,Sergio
author_facet	Alcaíno,Hernán Greig,Douglas Castro,Pablo Verdejo,Hugo Mellado,Rosemarie García,Lorena Díaz-Araya,Guillermo Quiroga,Clara Chiong,Mario Lavandero,Sergio
author_sort	Alcaíno,Hernán
title	Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
title_short	Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
title_full	Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
title_fullStr	Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
title_full_unstemmed	Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
title_sort	ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400014
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Ácido úrico: una molécula con acciones paradójicas en la insuficiencia cardiaca

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