Toxicidad del misoprostol sobre la gestación: Revisión de la literatura

Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-infammatory-induced gastric ulcers. Due to its uterotonic properties, it is also indicated in obstetrics for induction of la...

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Autor principal:	Cavieres,María Fernanda
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Abnormalities drug induced Abortion induced Misoprostol
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400015
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spelling	oai:scielo:S0034-988720110004000152011-08-25Toxicidad del misoprostol sobre la gestación: Revisión de la literaturaCavieres,María Fernanda Abnormalities drug induced Abortion induced Misoprostol Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-infammatory-induced gastric ulcers. Due to its uterotonic properties, it is also indicated in obstetrics for induction of labor and termination of pregnancy. In this last case, misoprostol is either used alone or in combination with other oxytocic drugs such as methotrexate or mifepristone. The use of misoprostol as an abortifacient agent is considered to be safe since it rarely causes serious side effects. However up to 15 % of misoprostol-induced-abortions may not be successful, even under medical supervision, leading to in utero exposure to the drug and to the induction of a series of birth defects including limb and joints defects and Moebius syndrome. Reports from the nineties failed to show a strong epidemiological association between in utero drug exposure and induction of defects, a situation that has changed now that the number of cases reported has increased. Since the practice of abortion is illegal in Chile, many women turn to off-medical procedures to interrupt their pregnancy and use misoprostol as an easy and cheap alternative, readily available in the INTERNET. The lack of medical supervision in these cases may lead to situations that favor the induction of congenital defects. Here, we present an updated review of scientifc data, to evaluate the risk of birth defects in babies exposed to the drug during pregnancy termination failed attempts.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.4 20112011-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400015es10.4067/S0034-98872011000400015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Abnormalities drug induced Abortion induced Misoprostol
spellingShingle	Abnormalities drug induced Abortion induced Misoprostol Cavieres,María Fernanda Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
description	Misoprostol, a synthetic analog of prostaglandin E1, is currently used in Chile and other countries as an antiulcer medication, mainly for the prevention of non-steroidal anti-infammatory-induced gastric ulcers. Due to its uterotonic properties, it is also indicated in obstetrics for induction of labor and termination of pregnancy. In this last case, misoprostol is either used alone or in combination with other oxytocic drugs such as methotrexate or mifepristone. The use of misoprostol as an abortifacient agent is considered to be safe since it rarely causes serious side effects. However up to 15 % of misoprostol-induced-abortions may not be successful, even under medical supervision, leading to in utero exposure to the drug and to the induction of a series of birth defects including limb and joints defects and Moebius syndrome. Reports from the nineties failed to show a strong epidemiological association between in utero drug exposure and induction of defects, a situation that has changed now that the number of cases reported has increased. Since the practice of abortion is illegal in Chile, many women turn to off-medical procedures to interrupt their pregnancy and use misoprostol as an easy and cheap alternative, readily available in the INTERNET. The lack of medical supervision in these cases may lead to situations that favor the induction of congenital defects. Here, we present an updated review of scientifc data, to evaluate the risk of birth defects in babies exposed to the drug during pregnancy termination failed attempts.
author	Cavieres,María Fernanda
author_facet	Cavieres,María Fernanda
author_sort	Cavieres,María Fernanda
title	Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
title_short	Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
title_full	Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
title_fullStr	Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
title_full_unstemmed	Toxicidad del misoprostol sobre la gestación: Revisión de la literatura
title_sort	toxicidad del misoprostol sobre la gestación: revisión de la literatura
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000400015
work_keys_str_mv	AT cavieresmariafernanda toxicidaddelmisoprostolsobrelagestacionrevisiondelaliteratura
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Toxicidad del misoprostol sobre la gestación: Revisión de la literatura

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