Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación

Background: Approximately 15% of misoprostol-induced-abortions may not be successful, leading to in utero exposure to the drug and to the induction of a series of defects including central nervous system, limb and visceral defects. A commonproposal is that the drug causes disruption of the fetal vas...

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Autores principales:	Campos E,Carolina, Cavieres,M. Fernanda
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Embryo culture techniques Misoprostol Teratology Toxicpotential
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000500008
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spelling	oai:scielo:S0034-988720110005000082011-09-16Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantaciónCampos E,CarolinaCavieres,M. Fernanda Embryo culture techniques Misoprostol Teratology Toxicpotential Background: Approximately 15% of misoprostol-induced-abortions may not be successful, leading to in utero exposure to the drug and to the induction of a series of defects including central nervous system, limb and visceral defects. A commonproposal is that the drug causes disruption of the fetal vasculature leading to embryonic or fetal hypoxia. Aim: To evaluate the teratogenicity of misoprostol using the rat post-implantation embryo culture. Material and Methods: Rat embryos were collected at the beginning of organogenesis and cultured in rat serum containing misoprostol at concentrations of 200, 2,000 or 20,000 pg/ml. Functionality, morphology and morphometry parameters were evaluated. Results: Misoprostol induced a dose-dependent embryotoxic effect causing a decrease in embryo viability and function (poor vascular development and survival) and morphometry (alterations in branchial arches, heart and cephalic portions of the neural tube, among others). Conclusions: All the manifestations observed are indicative of the ability of misoprostol to directly induce developmental retardation and alterations.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.5 20112011-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000500008es10.4067/S0034-98872011000500008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Embryo culture techniques Misoprostol Teratology Toxicpotential
spellingShingle	Embryo culture techniques Misoprostol Teratology Toxicpotential Campos E,Carolina Cavieres,M. Fernanda Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
description	Background: Approximately 15% of misoprostol-induced-abortions may not be successful, leading to in utero exposure to the drug and to the induction of a series of defects including central nervous system, limb and visceral defects. A commonproposal is that the drug causes disruption of the fetal vasculature leading to embryonic or fetal hypoxia. Aim: To evaluate the teratogenicity of misoprostol using the rat post-implantation embryo culture. Material and Methods: Rat embryos were collected at the beginning of organogenesis and cultured in rat serum containing misoprostol at concentrations of 200, 2,000 or 20,000 pg/ml. Functionality, morphology and morphometry parameters were evaluated. Results: Misoprostol induced a dose-dependent embryotoxic effect causing a decrease in embryo viability and function (poor vascular development and survival) and morphometry (alterations in branchial arches, heart and cephalic portions of the neural tube, among others). Conclusions: All the manifestations observed are indicative of the ability of misoprostol to directly induce developmental retardation and alterations.
author	Campos E,Carolina Cavieres,M. Fernanda
author_facet	Campos E,Carolina Cavieres,M. Fernanda
author_sort	Campos E,Carolina
title	Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
title_short	Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
title_full	Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
title_fullStr	Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
title_full_unstemmed	Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
title_sort	evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000500008
work_keys_str_mv	AT camposecarolina evaluaciondelaembriotoxicidaddemisoprostolutilizandoelensayocultivodeembrionespostimplantacion AT cavieresmfernanda evaluaciondelaembriotoxicidaddemisoprostolutilizandoelensayocultivodeembrionespostimplantacion
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Evaluación de la embriotoxicidad de misoprostol utilizando el ensayo cultivo de embriones postimplantación

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