Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer

Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neu-rological, neuropsychological, and neurobehavioral sequels. HSV-1 in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martin,Carolina, Solís,Loretto, Concha,Margarita I, Otth,Carola
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Alzheimer disease Encephalitis viral Herpesvirus 1 human
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000600013
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872011000600013
record_format	dspace
spelling	oai:scielo:S0034-988720110006000132011-09-14Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de AlzheimerMartin,CarolinaSolís,LorettoConcha,Margarita IOtth,Carola Alzheimer disease Encephalitis viral Herpesvirus 1 human Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neu-rological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system structures in the central nervous system (CNS), and has been suggested as an environmental risk factor for Alzheimers disease. The possibility that HSV-1 reactivates in CNS neurons causing chronic progressive damage at cellular level and altering the neuronal functionality has not been thoroughly investigated. Currently it is ignored if recurrent reactivation of HSV-1 in asymptomatic patients involves some risk of progressive deterioration of the CNS functions caused, in example, by a neuroinflammatory response against the virus or by direct toxicity of the pathogen on neurons. Therefore, studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.6 20112011-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000600013es10.4067/S0034-98872011000600013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alzheimer disease Encephalitis viral Herpesvirus 1 human
spellingShingle	Alzheimer disease Encephalitis viral Herpesvirus 1 human Martin,Carolina Solís,Loretto Concha,Margarita I Otth,Carola Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
description	Herpes simplex virus type 1 (HSV-1) is ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis is associated with a high mortality rate and significant neu-rological, neuropsychological, and neurobehavioral sequels. HSV-1 infects limbic system structures in the central nervous system (CNS), and has been suggested as an environmental risk factor for Alzheimers disease. The possibility that HSV-1 reactivates in CNS neurons causing chronic progressive damage at cellular level and altering the neuronal functionality has not been thoroughly investigated. Currently it is ignored if recurrent reactivation of HSV-1 in asymptomatic patients involves some risk of progressive deterioration of the CNS functions caused, in example, by a neuroinflammatory response against the virus or by direct toxicity of the pathogen on neurons. Therefore, studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance.
author	Martin,Carolina Solís,Loretto Concha,Margarita I Otth,Carola
author_facet	Martin,Carolina Solís,Loretto Concha,Margarita I Otth,Carola
author_sort	Martin,Carolina
title	Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
title_short	Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
title_full	Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
title_fullStr	Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
title_full_unstemmed	Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer
title_sort	herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de alzheimer
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000600013
work_keys_str_mv	AT martincarolina herpessimplexvirustipo1comofactorderiesgoasociadoconlaenfermedaddealzheimer AT solisloretto herpessimplexvirustipo1comofactorderiesgoasociadoconlaenfermedaddealzheimer AT conchamargaritai herpessimplexvirustipo1comofactorderiesgoasociadoconlaenfermedaddealzheimer AT otthcarola herpessimplexvirustipo1comofactorderiesgoasociadoconlaenfermedaddealzheimer
_version_	1718436571834744832

Herpes simplex virus tipo 1 como factor de riesgo asociado con la enfermedad de Alzheimer

Ejemplares similares