Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile
Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. Aim: To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2011
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| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700003 |
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oai:scielo:S0034-988720110007000032011-09-16Encuesta nacional online aplicada en pacientes con enfermedad celíaca en ChileEspino,AlbertoCastillo L,CeciliaGuiraldes,ErnestoSantibáñez,HelgaMiquel,Juan Francisco Biopsy Celiac disease Diet gluten free Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. Aim: To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean individuals with CD. Material and Methods: Subjects with confirmed or suspected CD were invited to answer an online survey published on the web at www.fundacionconvivir.cl. The answers were reinforced with a telephone interview. Results: The survey was answered by 1212 subjects (79% females). Median age at diagnosis was 25.8 years (range 1 to 84 years), with a bimodal curve with two peaks at less than 3 years and at 20 to 40 years of age. The diagnosis was made only by serologic markers in 9%, only by intestinal biopsy in 17.5%, and by a combination of both methods in 70%o. Conditions associated with CD were reported by 30%> of subjects and 20%> had relatives with CD. The GFD was strictly adhered to by 70%>, occasionally by 27%> and never by 3%>. Seventy five percent of subjects with a strict adherence to GFD had a favorable clinical response compared with 42%> of those with incomplete or lack of adherence (odds ratio 4.0, 95%> confidence intervals 2.8-5.7p < 0.01). Conclusions: In 30% of respondents, the diagnosis of CD was not confirmed according to international guidelines that require serology and duodenal biopsy. One third of subjects recognized a poor compliance with GFD. Those with a strict adherence to it had a more favorable clinical course. However, 25%> did not experience a clinical improvement despite a strict GFD, a finding which requires further study.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.7 20112011-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700003es10.4067/S0034-98872011000700003 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Biopsy Celiac disease Diet gluten free |
| spellingShingle |
Biopsy Celiac disease Diet gluten free Espino,Alberto Castillo L,Cecilia Guiraldes,Ernesto Santibáñez,Helga Miquel,Juan Francisco Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| description |
Background: Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Its prevalence in Europe and the USA is 0.5 to 1%. Aim: To analyze epidemiological aspects and degree of compliance with gluten-free diet (GFD) among Chilean individuals with CD. Material and Methods: Subjects with confirmed or suspected CD were invited to answer an online survey published on the web at www.fundacionconvivir.cl. The answers were reinforced with a telephone interview. Results: The survey was answered by 1212 subjects (79% females). Median age at diagnosis was 25.8 years (range 1 to 84 years), with a bimodal curve with two peaks at less than 3 years and at 20 to 40 years of age. The diagnosis was made only by serologic markers in 9%, only by intestinal biopsy in 17.5%, and by a combination of both methods in 70%o. Conditions associated with CD were reported by 30%> of subjects and 20%> had relatives with CD. The GFD was strictly adhered to by 70%>, occasionally by 27%> and never by 3%>. Seventy five percent of subjects with a strict adherence to GFD had a favorable clinical response compared with 42%> of those with incomplete or lack of adherence (odds ratio 4.0, 95%> confidence intervals 2.8-5.7p < 0.01). Conclusions: In 30% of respondents, the diagnosis of CD was not confirmed according to international guidelines that require serology and duodenal biopsy. One third of subjects recognized a poor compliance with GFD. Those with a strict adherence to it had a more favorable clinical course. However, 25%> did not experience a clinical improvement despite a strict GFD, a finding which requires further study. |
| author |
Espino,Alberto Castillo L,Cecilia Guiraldes,Ernesto Santibáñez,Helga Miquel,Juan Francisco |
| author_facet |
Espino,Alberto Castillo L,Cecilia Guiraldes,Ernesto Santibáñez,Helga Miquel,Juan Francisco |
| author_sort |
Espino,Alberto |
| title |
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| title_short |
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| title_full |
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| title_fullStr |
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| title_full_unstemmed |
Encuesta nacional online aplicada en pacientes con enfermedad celíaca en Chile |
| title_sort |
encuesta nacional online aplicada en pacientes con enfermedad celíaca en chile |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700003 |
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