Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico

Chronic hemodialysis patients may have recurrent bleeding from gastrointestinal angiodysplasia, that often is diffusely located in the digestive tract or in places difficult to reach with traditional endoscopes. Therefore, they cannot be locally treated or removed. We report a 70 years old man on ch...

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Autores principales:	Vega,Jorge, Goecke,Helmuth, Rodríguez,Mª De Los Ángeles, Vergara,Mª Teresa
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Angiodysplasia Renal dialysis Thalidomide
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700012
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spelling	oai:scielo:S0034-988720110007000122011-09-16Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínicoVega,JorgeGoecke,HelmuthRodríguez,Mª De Los ÁngelesVergara,Mª Teresa Angiodysplasia Renal dialysis Thalidomide Chronic hemodialysis patients may have recurrent bleeding from gastrointestinal angiodysplasia, that often is diffusely located in the digestive tract or in places difficult to reach with traditional endoscopes. Therefore, they cannot be locally treated or removed. We report a 70 years old man on chronic hemodialysis, with severe and persistent anemia due to bleeding from angiodysplasia of the small bowel. Despite administration of high doses of erythropoiesis stimulating agents, intravenous iron, folate, B6 and B12 vitamins, his hemoglobin levels were < 6.5g/dL, becoming totally dependent on transfusions ofred blood cells (up to 46 units per year). Recurrent bleeding was refractory to conventional management and we decided to use thalidomide at doses of 50-100 mg/day achieving rapid control of gastrointestinal bleeding and significant increase of hemoglobin levels, not requiring further transfusions.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.7 20112011-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700012es10.4067/S0034-98872011000700012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Angiodysplasia Renal dialysis Thalidomide
spellingShingle	Angiodysplasia Renal dialysis Thalidomide Vega,Jorge Goecke,Helmuth Rodríguez,Mª De Los Ángeles Vergara,Mª Teresa Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
description	Chronic hemodialysis patients may have recurrent bleeding from gastrointestinal angiodysplasia, that often is diffusely located in the digestive tract or in places difficult to reach with traditional endoscopes. Therefore, they cannot be locally treated or removed. We report a 70 years old man on chronic hemodialysis, with severe and persistent anemia due to bleeding from angiodysplasia of the small bowel. Despite administration of high doses of erythropoiesis stimulating agents, intravenous iron, folate, B6 and B12 vitamins, his hemoglobin levels were < 6.5g/dL, becoming totally dependent on transfusions ofred blood cells (up to 46 units per year). Recurrent bleeding was refractory to conventional management and we decided to use thalidomide at doses of 50-100 mg/day achieving rapid control of gastrointestinal bleeding and significant increase of hemoglobin levels, not requiring further transfusions.
author	Vega,Jorge Goecke,Helmuth Rodríguez,Mª De Los Ángeles Vergara,Mª Teresa
author_facet	Vega,Jorge Goecke,Helmuth Rodríguez,Mª De Los Ángeles Vergara,Mª Teresa
author_sort	Vega,Jorge
title	Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
title_short	Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
title_full	Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
title_fullStr	Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
title_full_unstemmed	Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico
title_sort	uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000700012
work_keys_str_mv	AT vegajorge usodetalidomidaensangradorecurrenteporangiodisplasiasgastrointestinalescasoclinico AT goeckehelmuth usodetalidomidaensangradorecurrenteporangiodisplasiasgastrointestinalescasoclinico AT rodriguezmadelosangeles usodetalidomidaensangradorecurrenteporangiodisplasiasgastrointestinalescasoclinico AT vergaramateresa usodetalidomidaensangradorecurrenteporangiodisplasiasgastrointestinalescasoclinico
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Uso de talidomida en sangrado recurrente por angiodisplasias gastrointestinales: Caso clínico

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