Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women
Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-α , and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of obser...
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Sociedad Médica de Santiago
2011
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oai:scielo:S0034-988720110008000042011-12-20Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian womenLindgärde,FolkeGottsäter,AndersAhrén,Bo Adiposity Exercise Interleukin-6 Physical fitness Tumor necrosis factor-alpha Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-α , and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of observation during which p-glucose deteriorated and weight increased, 44 Peruvian Amerindian women aged 20-59 years took part in a 6-month exercise program. Plasma TNF-α and IL-6 had been measured 5 years earlier, and were reassessed before and after exercise, using ELISA kits. Cardiorespiratory fitness was derived from the results of the twelve minutes walk and expressed as maximum oxygen uptake (VO2max). Results: After the training program, estimated VO2max increased from 18.55 ± 3.79 to 20.91 ± 4.61 mL kg-1 min-1 (p < 0.01) and p-TNF-α increased from 3.2 ± 3.4 to 4.3 ± 6.6 pg/mL (p = 0.03). There were reductions in p-glucose from 5.19 ± 1.59 to 4.32 ± 1.62 mmol/L (p < 0.01) and in waist circumference (p=0.01). Weight, p-insulin, and IL-6 did not change. Levels of p-glucose and p-TNF-α observed after the training period were identical to values 5 years earlier. P-TNF-α was positively associated with estimated VO2max, prior to (r = .414, p < 0.01) as well as after (r = .362, p < 0.05) exercise, independently of adiposity. P-IL-α was associated with waist circumference but not with estimated VO2max. Conclusions: P-TNF-a correlated with estimated VO2max independently of adiposity. Beneficial effects of exercise on p-glucose were observed in spite of an increase in p-TNF-α.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.8 20112011-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000800004en10.4067/S0034-98872011000800004 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
Adiposity Exercise Interleukin-6 Physical fitness Tumor necrosis factor-alpha |
| spellingShingle |
Adiposity Exercise Interleukin-6 Physical fitness Tumor necrosis factor-alpha Lindgärde,Folke Gottsäter,Anders Ahrén,Bo Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| description |
Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-α , and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of observation during which p-glucose deteriorated and weight increased, 44 Peruvian Amerindian women aged 20-59 years took part in a 6-month exercise program. Plasma TNF-α and IL-6 had been measured 5 years earlier, and were reassessed before and after exercise, using ELISA kits. Cardiorespiratory fitness was derived from the results of the twelve minutes walk and expressed as maximum oxygen uptake (VO2max). Results: After the training program, estimated VO2max increased from 18.55 ± 3.79 to 20.91 ± 4.61 mL kg-1 min-1 (p < 0.01) and p-TNF-α increased from 3.2 ± 3.4 to 4.3 ± 6.6 pg/mL (p = 0.03). There were reductions in p-glucose from 5.19 ± 1.59 to 4.32 ± 1.62 mmol/L (p < 0.01) and in waist circumference (p=0.01). Weight, p-insulin, and IL-6 did not change. Levels of p-glucose and p-TNF-α observed after the training period were identical to values 5 years earlier. P-TNF-α was positively associated with estimated VO2max, prior to (r = .414, p < 0.01) as well as after (r = .362, p < 0.05) exercise, independently of adiposity. P-IL-α was associated with waist circumference but not with estimated VO2max. Conclusions: P-TNF-a correlated with estimated VO2max independently of adiposity. Beneficial effects of exercise on p-glucose were observed in spite of an increase in p-TNF-α. |
| author |
Lindgärde,Folke Gottsäter,Anders Ahrén,Bo |
| author_facet |
Lindgärde,Folke Gottsäter,Anders Ahrén,Bo |
| author_sort |
Lindgärde,Folke |
| title |
Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| title_short |
Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| title_full |
Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| title_fullStr |
Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| title_full_unstemmed |
Positive correlation between tumor necrosis factor (TNF)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women |
| title_sort |
positive correlation between tumor necrosis factor (tnf)-α and cardiorespiratory fitness after six-months of regular aerobic exercise in peruvian amerindian women |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000800004 |
| work_keys_str_mv |
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| _version_ |
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