Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida

Background: The diagnosis and treatment of periampullary tumors represents a challenge for current medicine. Aim: To review the results of pancreaticoduodenectomy (PDD) in the treatment of periampullary tumors and to identify risk factors that impact the long-term survival. Patients and Methods: We...

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Autores principales:	Norero,Enrique, Viñuela,Eduardo, Báez,Sergio, Martínez,Cristian, Reyes,Julio, Kusanovic,Rodrigo, Sanhueza,Marcel, Aguayo,Gloria, Calvo,Alfonso, Mege,Rose Marie, Caracci,Mario, Díaz,Alfonso
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	Common bile duct neoplasms Pancreaticoduodenectomy Pancreatic neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000800006
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spelling	oai:scielo:S0034-988720110008000062011-12-20Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevidaNorero,EnriqueViñuela,EduardoBáez,SergioMartínez,CristianReyes,JulioKusanovic,RodrigoSanhueza,MarcelAguayo,GloriaCalvo,AlfonsoMege,Rose MarieCaracci,MarioDíaz,Alfonso Common bile duct neoplasms Pancreaticoduodenectomy Pancreatic neoplasms Background: The diagnosis and treatment of periampullary tumors represents a challenge for current medicine. Aim: To review the results of pancreaticoduodenectomy (PDD) in the treatment of periampullary tumors and to identify risk factors that impact the long-term survival. Patients and Methods: We performed a retrospective study of patients who underwent a PDD for periampullary tumors between 1993 and 2009. We reviewed perioperative results and long term survival. We performed a multivariate analysis for long-term survival. Results: A PDD was performed in 181 patients aged 58 ± 12 years (98 females). Piloric preservation was done in 53% and a pancreatogastric anastomosis was used in 94% of cases. Morbidity was 62% and postoperative mortality was 5.5%. Pancreatic cancer was the most frequent pathological finding in 41%, followed by ampullary cancer in 28% and distal bile duct cancer in 16%. Median survival was 17 months, with a five years survival of 24%. Survival for ampullary tumors was 28 months with a five years survival of 32%. The median and five years survival were 14 months and 16% for bile duct cancer and 11 months and 14% for pancreatic cancer. Multivariate analysis identified tumor type (pancreas /bile duct) and lymph node dissemination as independent predictors of mortality. Conclusions: One quarter of patients experienced long term survival. Mortality predictors were tumor type and lymph node dissemination.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.8 20112011-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000800006es10.4067/S0034-98872011000800006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Common bile duct neoplasms Pancreaticoduodenectomy Pancreatic neoplasms
spellingShingle	Common bile duct neoplasms Pancreaticoduodenectomy Pancreatic neoplasms Norero,Enrique Viñuela,Eduardo Báez,Sergio Martínez,Cristian Reyes,Julio Kusanovic,Rodrigo Sanhueza,Marcel Aguayo,Gloria Calvo,Alfonso Mege,Rose Marie Caracci,Mario Díaz,Alfonso Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
description	Background: The diagnosis and treatment of periampullary tumors represents a challenge for current medicine. Aim: To review the results of pancreaticoduodenectomy (PDD) in the treatment of periampullary tumors and to identify risk factors that impact the long-term survival. Patients and Methods: We performed a retrospective study of patients who underwent a PDD for periampullary tumors between 1993 and 2009. We reviewed perioperative results and long term survival. We performed a multivariate analysis for long-term survival. Results: A PDD was performed in 181 patients aged 58 ± 12 years (98 females). Piloric preservation was done in 53% and a pancreatogastric anastomosis was used in 94% of cases. Morbidity was 62% and postoperative mortality was 5.5%. Pancreatic cancer was the most frequent pathological finding in 41%, followed by ampullary cancer in 28% and distal bile duct cancer in 16%. Median survival was 17 months, with a five years survival of 24%. Survival for ampullary tumors was 28 months with a five years survival of 32%. The median and five years survival were 14 months and 16% for bile duct cancer and 11 months and 14% for pancreatic cancer. Multivariate analysis identified tumor type (pancreas /bile duct) and lymph node dissemination as independent predictors of mortality. Conclusions: One quarter of patients experienced long term survival. Mortality predictors were tumor type and lymph node dissemination.
author	Norero,Enrique Viñuela,Eduardo Báez,Sergio Martínez,Cristian Reyes,Julio Kusanovic,Rodrigo Sanhueza,Marcel Aguayo,Gloria Calvo,Alfonso Mege,Rose Marie Caracci,Mario Díaz,Alfonso
author_facet	Norero,Enrique Viñuela,Eduardo Báez,Sergio Martínez,Cristian Reyes,Julio Kusanovic,Rodrigo Sanhueza,Marcel Aguayo,Gloria Calvo,Alfonso Mege,Rose Marie Caracci,Mario Díaz,Alfonso
author_sort	Norero,Enrique
title	Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
title_short	Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
title_full	Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
title_fullStr	Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
title_full_unstemmed	Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
title_sort	resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000800006
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Resultados actuales de la pancreatoduodenectomía para el tratamiento de los tumores periampulares y análisis de factores pronósticos de sobrevida

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