Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años
Background: Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 199...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2011
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oai:scielo:S0034-988720110009000052011-11-17Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 añosRodríguez,CarlosRojas,PabloWozniak,AnielaKalergis,Alexis MCerón,InésRiedel,IngridRomán,Juan CVillarroel,Luis ABerríos,XimenaBavestrello,LuisGarcía,Patricia Drug resistance, bacterial Genetic markers Streptococcus pyogenes Background: Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one. Aim: To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005. Material and Methods: Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes. Results: Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype. Conclusions: Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.9 20112011-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000900005es10.4067/S0034-98872011000900005 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Drug resistance, bacterial Genetic markers Streptococcus pyogenes |
| spellingShingle |
Drug resistance, bacterial Genetic markers Streptococcus pyogenes Rodríguez,Carlos Rojas,Pablo Wozniak,Aniela Kalergis,Alexis M Cerón,Inés Riedel,Ingrid Román,Juan C Villarroel,Luis A Berríos,Ximena Bavestrello,Luis García,Patricia Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| description |
Background: Macrolide and lincosamide resistance in Streptococcus pyogenes is due to the acquisition of mef, ermB and ermA genes, which confer different resistance phenotypes, namely M, MLSBconstitutive and MLSBinducible respectively. The last report of resistance in Chile was done in the period 1990-1998, in which resistance to macrolides was 5.4%, with M phenotype as the predominant one. Aim: To characterize the evolution of erythromycin and clindamycin resistance and their associated genes in S. pyogenes strains isolated from patients with invasive and non-invasive infections in the period 1996 to 2005. Material and Methods: Resistance to erythromycin and clindamycin was determined in 1,282 clinical isolates using the disk diffusion test. Resistant isolates were analyzed by polymerase chain reaction (PCR) for the presence of the above mentioned resistance genes. Results: Global resistance to erythromycin and clindamycin was 3.5 and 0.7% respectively. Eighty percent of the resistant strains possessed the M. phenotype. Conclusions: Resistance levels of S. pyogenes have decreased in Chile in the last years. Most resistant strains have M phenotype in contrast to many countries in which the MLSB constitutive phenotype is the predominant one. |
| author |
Rodríguez,Carlos Rojas,Pablo Wozniak,Aniela Kalergis,Alexis M Cerón,Inés Riedel,Ingrid Román,Juan C Villarroel,Luis A Berríos,Ximena Bavestrello,Luis García,Patricia |
| author_facet |
Rodríguez,Carlos Rojas,Pablo Wozniak,Aniela Kalergis,Alexis M Cerón,Inés Riedel,Ingrid Román,Juan C Villarroel,Luis A Berríos,Ximena Bavestrello,Luis García,Patricia |
| author_sort |
Rodríguez,Carlos |
| title |
Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| title_short |
Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| title_full |
Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| title_fullStr |
Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| title_full_unstemmed |
Análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de Streptococcus pyogenes aisladas en Chile en un período de 10 años |
| title_sort |
análisis de los fenotipos y genotipos de resistencia a eritromicina y clindamicina en cepas de streptococcus pyogenes aisladas en chile en un período de 10 años |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011000900005 |
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