Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia

Background: There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. However systematic reviews of the existing evidence have shown that such association varies across populations with different genetic ancestry. Aim: To evaluate the association of IL-1B-511 and IL-1RN po...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Martínez,Teresa, Hernández-Suárez,Gustavo, Mercedes Bravo,María, Trujillo,Esperanza, Quiroga,Andrés, Albis,Rosario, Robayo,Juan C, Bravo,Juan Carlos, Camorlinga,Margarita
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2011
Materias:	CgA protein, Helicobacter pylori Colombia Interleukin-1beta Polymorphism genetic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000010
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872011001000010
record_format	dspace
spelling	oai:scielo:S0034-988720110010000102012-01-03Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en ColombiaMartínez,TeresaHernández-Suárez,GustavoMercedes Bravo,MaríaTrujillo,EsperanzaQuiroga,AndrésAlbis,RosarioRobayo,Juan CBravo,Juan CarlosCamorlinga,Margarita CgA protein, Helicobacter pylori Colombia Interleukin-1beta Polymorphism genetic Background: There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. However systematic reviews of the existing evidence have shown that such association varies across populations with different genetic ancestry. Aim: To evaluate the association of IL-1B-511 and IL-1RN polymorphism and Helicobacter pylori IgG antibodies CagA, with gastric cancer in two Colombian cities located in a high risk area for gastric cancer. Material and Methods: A case-control study including 46 gastric cancer cases and 99 controls with non-atrophic gastritis from a high risk zone for gastric cancer. Polymorphism genotyping was carried out by polymerase chain reaction (PCR) and IgG CagA status by ELISA. Results: IgG CagA seropositive individuals had an increased gastric cancer risk (odds ratio (OR) = 11.56; 95% confidence intervals (CI) 2.62-50.91 in Tunja and OR = 19.66, 95%CI 0.98-395 in Bogotá). IL-1B-511TT carriers in Tunja had increased risk of gastric cancer (OR = 11.31; 95%CI 1.20-106.54)), while IL-1RN*2 alelle carriers in Bogotá showed an inverse association with gastric cancer risk (OR = 0.03; 95%CI 0.01-0.65). Conclusions: This study adds evidence to the positive association of Helicobacter pylori CagA positive strains with non-cardial gastric cancer etiology. There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.10 20112011-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000010es10.4067/S0034-98872011001000010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	CgA protein, Helicobacter pylori Colombia Interleukin-1beta Polymorphism genetic
spellingShingle	CgA protein, Helicobacter pylori Colombia Interleukin-1beta Polymorphism genetic Martínez,Teresa Hernández-Suárez,Gustavo Mercedes Bravo,María Trujillo,Esperanza Quiroga,Andrés Albis,Rosario Robayo,Juan C Bravo,Juan Carlos Camorlinga,Margarita Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
description	Background: There is an association of interleukin (IL)1B polymorphism with gastric cancer risk. However systematic reviews of the existing evidence have shown that such association varies across populations with different genetic ancestry. Aim: To evaluate the association of IL-1B-511 and IL-1RN polymorphism and Helicobacter pylori IgG antibodies CagA, with gastric cancer in two Colombian cities located in a high risk area for gastric cancer. Material and Methods: A case-control study including 46 gastric cancer cases and 99 controls with non-atrophic gastritis from a high risk zone for gastric cancer. Polymorphism genotyping was carried out by polymerase chain reaction (PCR) and IgG CagA status by ELISA. Results: IgG CagA seropositive individuals had an increased gastric cancer risk (odds ratio (OR) = 11.56; 95% confidence intervals (CI) 2.62-50.91 in Tunja and OR = 19.66, 95%CI 0.98-395 in Bogotá). IL-1B-511TT carriers in Tunja had increased risk of gastric cancer (OR = 11.31; 95%CI 1.20-106.54)), while IL-1RN*2 alelle carriers in Bogotá showed an inverse association with gastric cancer risk (OR = 0.03; 95%CI 0.01-0.65). Conclusions: This study adds evidence to the positive association of Helicobacter pylori CagA positive strains with non-cardial gastric cancer etiology. There is a possible heterogeneity in the association of IL-1B gene polymorphism with cancer, in populations of similar ethnic background and settled in the same risk area.
author	Martínez,Teresa Hernández-Suárez,Gustavo Mercedes Bravo,María Trujillo,Esperanza Quiroga,Andrés Albis,Rosario Robayo,Juan C Bravo,Juan Carlos Camorlinga,Margarita
author_facet	Martínez,Teresa Hernández-Suárez,Gustavo Mercedes Bravo,María Trujillo,Esperanza Quiroga,Andrés Albis,Rosario Robayo,Juan C Bravo,Juan Carlos Camorlinga,Margarita
author_sort	Martínez,Teresa
title	Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
title_short	Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
title_full	Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
title_fullStr	Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
title_full_unstemmed	Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia
title_sort	asociación de los polimorfismos il-1b-511 e il-1rn y helicobacter pylori caga positivo con cáncer gástrico en una zona de riesgo alto en colombia
publisher	Sociedad Médica de Santiago
publishDate	2011
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000010
work_keys_str_mv	AT martinezteresa asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT hernandezsuarezgustavo asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT mercedesbravomaria asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT trujilloesperanza asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT quirogaandres asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT albisrosario asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT robayojuanc asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT bravojuancarlos asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia AT camorlingamargarita asociaciondelospolimorfismosil1b511eil1rnyhelicobacterpyloricagapositivoconcancergastricoenunazonaderiesgoaltoencolombia
_version_	1718436592594452480

Asociación de los polimorfismos IL-1B-511 e IL-1RN y Helicobacter pylori CagA positivo con cáncer gástrico en una zona de riesgo alto en Colombia

Ejemplares similares