Nuevos anticoagulantes orales

Thromboembolic disease (TED) is the leading cause of morbidity and mortality worldwide. The hallmark of oral long-term anticoagulant therapy has been the use of vitamin K antagonists, whose anticoagulant effect is exerted inhibiting vitamin K epoxide reductase. Warfarin and acenocoumarol are the mos...

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Autores principales: Berkovits,Alejandro, Aizman,Andrés, Zúñiga,Pamela, Pereira,Jaime, Mezzano,Diego
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2011
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000016
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spelling oai:scielo:S0034-988720110010000162012-01-03Nuevos anticoagulantes oralesBerkovits,AlejandroAizman,AndrésZúñiga,PamelaPereira,JaimeMezzano,Diego Anticoagulants Haemostasis Thrombosis Thromboembolic disease (TED) is the leading cause of morbidity and mortality worldwide. The hallmark of oral long-term anticoagulant therapy has been the use of vitamin K antagonists, whose anticoagulant effect is exerted inhibiting vitamin K epoxide reductase. Warfarin and acenocoumarol are the most commonly used. In the last five years several new drugs for long term anticoagulation have been developed, which can inhibit single clotting factors with the purpose of improving drug therapeutic range and, ideally, minimizing bleeding risks. This review addresses the state of the art on the clinical use of inhibitors of activated factor X and thrombin.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.10 20112011-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000016es10.4067/S0034-98872011001000016
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Anticoagulants
Haemostasis
Thrombosis
spellingShingle Anticoagulants
Haemostasis
Thrombosis
Berkovits,Alejandro
Aizman,Andrés
Zúñiga,Pamela
Pereira,Jaime
Mezzano,Diego
Nuevos anticoagulantes orales
description Thromboembolic disease (TED) is the leading cause of morbidity and mortality worldwide. The hallmark of oral long-term anticoagulant therapy has been the use of vitamin K antagonists, whose anticoagulant effect is exerted inhibiting vitamin K epoxide reductase. Warfarin and acenocoumarol are the most commonly used. In the last five years several new drugs for long term anticoagulation have been developed, which can inhibit single clotting factors with the purpose of improving drug therapeutic range and, ideally, minimizing bleeding risks. This review addresses the state of the art on the clinical use of inhibitors of activated factor X and thrombin.
author Berkovits,Alejandro
Aizman,Andrés
Zúñiga,Pamela
Pereira,Jaime
Mezzano,Diego
author_facet Berkovits,Alejandro
Aizman,Andrés
Zúñiga,Pamela
Pereira,Jaime
Mezzano,Diego
author_sort Berkovits,Alejandro
title Nuevos anticoagulantes orales
title_short Nuevos anticoagulantes orales
title_full Nuevos anticoagulantes orales
title_fullStr Nuevos anticoagulantes orales
title_full_unstemmed Nuevos anticoagulantes orales
title_sort nuevos anticoagulantes orales
publisher Sociedad Médica de Santiago
publishDate 2011
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001000016
work_keys_str_mv AT berkovitsalejandro nuevosanticoagulantesorales
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AT zunigapamela nuevosanticoagulantesorales
AT pereirajaime nuevosanticoagulantesorales
AT mezzanodiego nuevosanticoagulantesorales
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