Insulinemia e índice HOMA en niños y adolescentes chilenos
Background: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years,...
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| Lenguaje: | Spanish / Castilian |
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Sociedad Médica de Santiago
2011
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oai:scielo:S0034-988720110011000072012-02-08Insulinemia e índice HOMA en niños y adolescentes chilenosBarja,SalesaArnaiz,PilarDomínguez,AngélicaVillarroel,LuisCassis,BertaCastillo,OscarSalomó,GianinaFarías,MarceloGoycoolea,ManuelaQuiroga,TeresaMardones,Francisco Adolescent Child Insulin resistance Background: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. Material and Methods: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. Results: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 ± 6.0 and 9.1 ± 4.9 μϋ/mL (p < 0.01) and 2.7 ± 1.4 and 2.1 ± 1,1 (p < 0.01), respectively). Subjects with Tanner I and IIpuberal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 ± 4.3 and 12.5 ± 6.2μϋ/ml (p < 0.01) and2.0 ± 1 and2.8 ± 1.4 (p < 0.01), respectively). Conclusions: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner I and II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.139 n.11 20112011-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001100007es10.4067/S0034-98872011001100007 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Adolescent Child Insulin resistance |
| spellingShingle |
Adolescent Child Insulin resistance Barja,Salesa Arnaiz,Pilar Domínguez,Angélica Villarroel,Luis Cassis,Berta Castillo,Oscar Salomó,Gianina Farías,Marcelo Goycoolea,Manuela Quiroga,Teresa Mardones,Francisco Insulinemia e índice HOMA en niños y adolescentes chilenos |
| description |
Background: Plasma insulin and HOMA (homeostasis model assessment) index, used to determine insulin resistance, do not have local standard values for children and adolescents in Chile. Aim: To establish the normal reference intervals for insulin and HOMA in children and adolescents aged 10-15 years, according to sex and puberal maturation. Material and Methods: A cross-sectional study of 2,153 children and adolescents from Puente Alto County was performed, during 2009 and 2010. Anthropometry and self-report of puberal maturation were assessed. Fasting glucose (hexoquinase) and insulin blood levels (chemiluminiscence), were determined and HOMA index was calculated. Percentile distributions of these variables were calculated. Results: The reference group included only subjects with normal body mass index and fasting blood glucose (n = 1,192). Girls had higher insulin and HOMA values than boys (12.5 ± 6.0 and 9.1 ± 4.9 μϋ/mL (p < 0.01) and 2.7 ± 1.4 and 2.1 ± 1,1 (p < 0.01), respectively). Subjects with Tanner I and IIpuberal stages had lower insulin and HOMA mean values than subjects with Tanner III and IV (9.0 ± 4.3 and 12.5 ± 6.2μϋ/ml (p < 0.01) and2.0 ± 1 and2.8 ± 1.4 (p < 0.01), respectively). Conclusions: The 90th percentile of insulin and HOMA distributions according to sex and maturation, was selected as the upper cut-off point to identify individuals with insulin resistance. HOMA cutoff point for Tanner I and II boys was 3.2, for Tanner I and II girls was 4.1, for Tanner III and IV boys was 4.2 and for Tanner III and IV girls was 5.0. |
| author |
Barja,Salesa Arnaiz,Pilar Domínguez,Angélica Villarroel,Luis Cassis,Berta Castillo,Oscar Salomó,Gianina Farías,Marcelo Goycoolea,Manuela Quiroga,Teresa Mardones,Francisco |
| author_facet |
Barja,Salesa Arnaiz,Pilar Domínguez,Angélica Villarroel,Luis Cassis,Berta Castillo,Oscar Salomó,Gianina Farías,Marcelo Goycoolea,Manuela Quiroga,Teresa Mardones,Francisco |
| author_sort |
Barja,Salesa |
| title |
Insulinemia e índice HOMA en niños y adolescentes chilenos |
| title_short |
Insulinemia e índice HOMA en niños y adolescentes chilenos |
| title_full |
Insulinemia e índice HOMA en niños y adolescentes chilenos |
| title_fullStr |
Insulinemia e índice HOMA en niños y adolescentes chilenos |
| title_full_unstemmed |
Insulinemia e índice HOMA en niños y adolescentes chilenos |
| title_sort |
insulinemia e índice homa en niños y adolescentes chilenos |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2011 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872011001100007 |
| work_keys_str_mv |
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